国产盐酸头孢甲肟的制备  

The preparation process of domestic cefmenoxime hydrochloride

作　　者：黄金龙 应卫 施存元 庞雄 刘家健 刘敦茀 游莉 石克金 张晓 

机构地区：[1]浙江尖峰药业有限公司,金华321000 [2]中国医药集团四川抗菌素工业研究所,成都610051

出　　处：《中国抗生素杂志》2005年第7期396-398,共3页Chinese Journal of Antibiotics

摘　　要：以3-[[(1-甲基-1H-四唑-5-基)硫]甲基]-7-氨基-头孢烷酸盐酸盐(7-ATCA.HC l)为原料,在C7-NH2位置上用活性酯法与侧链化合物2-(2-氨基-4-噻唑基-2-(Z)-甲氧亚胺基乙酸缩合得到头孢甲肟,然后在水溶液中与盐酸成盐而制得盐酸头孢甲肟。以7-ATCA.HC l为基准,总合成收率在66%以上,产物为高纯度结晶性粉末。This paper describes the preparation process of cefmenoxime hydrochloride [(CMX)_2·HCl]. 3-[(1-methyl-1H-tetrazol-5-yl-thio)-methyl]-7-amino-cephalosporanic acid hydrochloride (7-ATCA·HCl) as the starting material, was condensed with the side chain compound 2-(2-amino-4-thiazol)-2(z)methyloxy-imino acetic acid on C_7- position via the active ester method and then the condensed product cefmenoxime (CMX) might be converted to its hydrochloride [(CMX)_2·HCl]. The total yield of the process was more than 66% (based on 7-ATCA·HCl). The product was obtained as a crystalline powder in high purity.

关 键 词：头孢甲肟 盐酸头孢甲肟 7-ATCA·HCl 氨噻肟乙酸 合成 

分 类 号：R978.11[医药卫生—药品]