僵知饮对四氧嘧啶诱导大鼠糖尿病的试验研究  

The study of the Jiangzhiyin on the diabetes rat induced by alloxan

作　　者：孙云[1] 徐峰[1] 王德俊[1] 陈琦[1] 

机构地区：[1]扬州大学医学院,江苏扬州225001

出　　处：《扬州大学学报（农业与生命科学版）》2005年第2期15-17,共3页Journal of Yangzhou University：Agricultural and Life Science Edition

基　　金：江苏省中医药管理局资助项目(K0110276)

摘　　要：采用静脉注射四氧嘧啶诱导大鼠化学性糖尿病,观察僵知饮对动物血糖、血脂和氧自由基的影响,以期治疗实验性糖尿病。结果表明:与模型组比较,僵知饮组空腹时血糖、甘油三酯和脂质过氧化物均显著降低(P<0.05～0.01),而全血超氧化物歧化酶活性明显升高(P<0.01),说明僵知饮治疗实验动物化学性糖尿病不仅降糖效果优于甲苯磺丁脲,且有降血脂、改善氧自由基代谢紊乱等多方面的药理活性,从而有助于防治糖尿病的并发症。<Abstrcat> To study the therapeutic effect of the Jiangzhiyin on the diabetes. The chemical diabetes rats model was induced by the alloxan iv. The metabolism of blood sugar, blood lipid and oxygen-derived free radicles were observed. Compared to the model group, the concentration of the blood sugar, the triglyceride, and lipid peroxidation of the Jiangzhiyin group decreased obviously, but the activity of superoxide dismutase increased. The Jiangzhiyin could have better effect than tolbutanmide on the chemical diabetes through the decreasing the blood lipid, improving the metabolism turbulence of oxygen-derived free adidicals, and preventing the side effect of diabetes. So Jiangzhiyyin had an affirmative effect on the diabetes.

关 键 词：僵知饮 四氧嘧啶 糖尿病 血糖 血脂 氧自由基 

分 类 号：R587.1[医药卫生—内分泌]