兴奋性氨基酸受体的分子生物学  

MOLECULAR BIOLOGY OF EXCITATORY AMINO ACID RECEPTORS

作　　者：魏东升[1] 胡国渊[1] 

机构地区：[1]中国科学院上海药物研究所新药研究国家重点实验室

出　　处：《神经科学》1994年第1期43-50,共8页Chinese Journal of Neuroscience

摘　　要：近年来分子生物学技术的应用使兴奋性氨基酸受体的研究取得重大突破，分属两个受体超家族的二十余种亚基已被克隆。兴奋性氨基酸的复杂作用源于受体的多型性，受体的多型性则来自不同亚基组合方式的变化。Molecular cloning has revealed the existence of more than twenty subunits of excitatory amino acid receptors, which belong to the two receptor-superfamilies.The diversity of the effects of excitatiory amino acids in the brain is derived from the receptor heterogeneity which is due to the increasing number of cloned subunits assembling in different pattern. The progresses in research on the relationship between the primary sequences of receptor subunits and their functions, and on the mechanisms of gene expression regulation will reveal the biological implications of the molecular diversity of excitatory amino acid receptors.

关 键 词：受体 兴奋性氨基酸 分子生物学 

分 类 号：Q517[生物学—生物化学] R338[医药卫生—人体生理学]