脉心康胶囊对颈动脉粥样硬化病人肱动脉内皮依赖性舒张功能的影响  

Effect of Maixinkang Capsule on Brachial Artery Endothelium Dependent Vasodilation Function in Patients with Carotid Atherosclerosis

作　　者：郑广娟[1] 张文高[1] 蔚青[1] 殷镜海[2] 刘龙涛[1] 王大智 王显刚[1] 

机构地区：[1]山东中医药大学 [2]山东中医药大学附属医院 [3]山东省济南炼油厂职工医院

出　　处：《中西医结合心脑血管病杂志》2005年第7期567-568,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：山东省自然基金课题(No.Y2001C14)

摘　　要：目的观察脉心康胶囊对颈动脉粥样硬化的临床疗效。方法将30例颈动脉粥样硬化病人随机分为脉心康组与洛伐他汀组各15例。另外15例颈动脉粥样硬化病人作为空白组对照。观察用药6个月对临床症状的影响,用彩色超声多普勒检测肱动脉内皮依赖性舒张功能(FMD)。结果两治疗组临床症状总疗效、总有效率比较无统计学意义,脉心康组显效率(73.33%)明显优于洛伐他汀组(26.67%)。两治疗组治疗后FMD显著改善,两组间比较无统计学意义;两治疗组对颈动脉粥样硬化的控制显效率、总有效率明显地优于空白组。结论脉心康胶囊与洛伐他汀均有改善颈动脉粥样硬化及血管内皮依赖性舒张功能的作用。Objective To analyze the clinical effect of Maixinkang Capsule on carotid atherosclerosis.Methods Thirty patients (pts) with carotid atherosclerosis were divided into two groups randomly: Maixinkang Group and Lovastatin Group.Fifteen pts with carotid atherosclerosis were treated as the control group.Following the treatment for 6 months, the brachial artery endothelium-dependent vasodilation function (FMD) was collected by color ultrasonic doppler.Results There was no difference in total clinical effects between treatment groups.The effective rate in Maixinkang group (73.33%) was superior to Lovastatin group (26.67%) significantly.FMD improved in two treatment groups following treatment for six months.There was no difference between them. The effective rate in treatment groups was superior to control group.Conclusion Both of Maixinkang capsule and Lovastatin could be able to improve clinical symptoms and FMD in pts with carotid atherosclerosis.

关 键 词：脉心康胶囊 颈动脉粥样硬化 内皮依赖性舒张功能 

分 类 号：R259[医药卫生—中西医结合]