辛伐他汀的波谱学数据和结构确证  

Spectral Data Analysis and Identification of Simvastatin

作　　者：刘春河[1] 刘河[1] 陈兰福[1] 韩翔宇[1] 仲伯华[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《分析化学》2005年第7期985-988,共4页Chinese Journal of Analytical Chemistry

摘　　要：对辛伐他汀的红外(IR)、紫外(UV)、质谱(MS)、氢氢相关谱(1H1HCOSY)、碳谱(13CNMR,DEPT)、碳氢相关谱(HMQC)、碳氢远程相关谱(HMBC)予以解析并进行了报道,对所有的1HNMR和13CNMR谱信号进行了归属;讨论了红外特征吸收峰所对应的官能团的振动形式,并且对样品进行热差和热重分析,显示该样品为单一晶型,不含结晶水。The infrared spectrum, ultraviolet spectrum, mass spectrum, H-1-'H correlated spectroscopy (H-1-H-1 COSY), (H-1 detected) heteronuclear multiple-quantum coherence( HMQC), (H-1 detected) heteronuclear multiple-bond coherence(HMBC) of simvastatin were reported and interpreted. All the H-1 nuclear magnetic resonance (NMR) and C-13 NMR chemical shift were assigned by means of H-1-H-1 COSY, HMQC and HMBC. The vibrations of functional groups of this compound were discussed.

关 键 词：辛伐他汀 波谱学 结构 数据 特征吸收峰 相关谱 ^13C NMR谱 振动形式 热重分析 ^1H 官能团 结晶水 红外 碳氢 样品 质谱 碳谱 

分 类 号：TQ463.2[化学工程—制药化工]