PCR法检测非甲-庚型肝炎患者血清输血传播病毒及临床意义  

Transfusion Transmitted Virus Detected by Hn-PCR in serum of Patients with Hepatitis Non-A to G and it's Clinical Significance

作　　者：谭奕洲[1] 李穗芬[1] 唐漾波[1] 刘丽儿[1] 

机构地区：[1]广州市第八人民医院,广州市传染病研究所,广东广州510060

出　　处：《实用医技杂志》2005年第06B期1547-1549,共3页Journal of Practical Medical Techniques

摘　　要：目的:探讨输血传播病毒(transfusiontransmittedvirus,TTV)的实验室诊断及临床特点。方法:用半巢式聚合酶链反应方法检测50例非甲-庚型肝炎患者血清中TTV-DNA。结果:50例非甲-庚型肝炎患者血清中,有11例检出TTV-DNA。TTV感染者病程有轻有重,表现为急性无黄疸性肝炎、急性黄疸性肝炎及轻度慢性肝炎。结论:非甲-庚型肝炎患者血清中存在TTV的感染,并可能是致病原因。临床表现为急性或轻度慢性肝炎,组织学上可见肝细胞变性、坏死和肝组织淋巴细胞浸润、纤维增生、汇管区炎症。TTV除血传播外,可能存在其他的传播方式。Objective To study laboratory diagnosis of transfusion transmitted virus(TTV) and it's clinical character.Methods TTV-DNA in serum of 50 patients with hepatitis Non-A to G were detected by Hn-PCR.Results 11/50 of patients with hepatitis Non-A to G were detected TTV-DNA.The symptom of patients infected with TTV could be gently or severely, and it's clinical manifestations were acute non-icteric hepatitis、acute icteric hepatitis or mild chronic hepatitis.Conclusions Patients with hepatitis Non-A to G were infected with TTV probably,and TTV could be one of reasons to cause the disease.The clinical manifestations of patients infected with TTV were acute or mild chronic hepatitis, and liver cell degeneration、necrosis or liver tissue infiltrated with lymphocyte、fibrosum proliferation、inflammation could be seen on histology. There were some other ways of TTV transmission except blood.

关 键 词：非甲-非庚型肝炎 输血传播病毒 聚合酶链反应 

分 类 号：R512.6[医药卫生—内科学]