母乳前列腺素E_2含量与婴儿生理性腹泻关系及其治疗研究  

RESEARCH ABOUT THE RELATION OF PGE_2 LEVEL IN MOTHER MILK AND THE PHYSIOLOGICAL DIARRHEAOF THE BABY AND TREATMENET

作　　者：李绍云[1] 耿志超[1] 高永丽[1] 王爱珍[2] 王浩丹[3] 王维岳 

机构地区：[1]山东省千佛山医院小儿产,250014 [2]山东省千佛山医院妇产科,250014 [3]山东医科大学同位素中心实验室,250012

出　　处：《中华儿童保健杂志》1994年第2期81-83,共3页

摘　　要：母乳喂养婴儿常见生理性腹泻,为探索母乳与生理性腹泻的关系,我们应用放射免疫分析法测定了320例产后4个月内健康母乳前列腺素E_2(PGE_2)含量,其均值为0.623±0.417μmol/L,腹泻组143例母乳PGE_2为0.823±0.409μmol/L;非腹泻组177例母乳PGE_2含量为0.375±0。219μmol/L,两者相比P<0.001。提示母乳PGE_2含量过高可能是婴儿生理性腹泻的重要原因。母乳PGE_2含量个体差异明显(0.046～2.823μmol/L),婴儿腹泻次数与母乳PGE_2含量呈正相关(r=0.75,P<0.01)。本文对102例母乳PGE_2含量高婴儿又有明显生理性腹泻者用随机分组法进行治疗观察,治疗组52例哺乳妇女口服消炎痛25mg每日2次,7～10天为1疗程,治疗前母乳PGE_2含量为0.950±0.449μmol/L,治疗后母乳PGE_2为0.409±0.173μmol/L,两者相比P<0.001,有高度显著性差异,同时见婴儿腹泻治愈46例,好转4例,总有效率96.15％。治疗中婴儿无任何副作用;哺乳妇女2例轻微副作用在停药后迅速消失。而安慰剂组50例用药后母乳PGE_2含量及婴儿腹泻均无改变。It often occuerecl that the physiological diarrhea of bady fed on mother milk. To research the relation of mother milk and the physiological diarrhea of baby. We measured the PGE2 levels in mother milk of 320 women within 4-month postpartum with radioim-munoassay, the PGE2 levels were 0. 623±0. 417μmol/L. The PGE2 levels in mother milk of diarrhea group were 0. 823±0. 409μmol/L, that of control group 0. 375±0. 219μmol/L. The difference was obviously significant ( P <0. 001). The physiological diarrhea times of baby was positively related to the PGE2 level in mother milk( r =0. 75, P <0. 01). It showed that the high PGE2 level in mother milk may be an important cause of diseases. We observed 102 cases of baby with severe physiological diarrhea. while the PGE2 level in the mother milk was high, and treated the diarrhea with control. 52 cases of lactating women of therapy group took indomethacin. Aften treatment, the PEG2 level in mother milk decreased obviously ,and the diarrhea of baby disappeared. The effective ration 96. 15% No sideeffect to the baby,No effect in control group.

关 键 词：母乳 前列腺素E2 婴儿 生理性腹泻 

分 类 号：Q592.6[生物学—生物化学] R723.11[医药卫生—儿科]