心力衰竭患者血浆白细胞介素-12、白细胞介素-18和γ-干扰素水平变化及意义  

Plasma interleukin-12,interleukin-18 and interferon-γin patients with heart failure.

作　　者：许金成[1] 王淑斐[1] 凌文革[1] 梁庆祥[1] 

机构地区：[1]南方医科大学附属深圳宝安医院心内科,广东省深圳市518101

出　　处：《中国综合临床》2005年第8期673-675,共3页Clinical Medicine of China

基　　金：广东省卫生厅科研基金资助(A2001488)

摘　　要：目的探讨白细胞介素-12(IL-12)、白细胞介素-18(IL-18)及γ-干扰素(IFN-γ)在心力衰竭发生与发展中的作用及相互关系。方法应用酶联免疫吸附法测定36例心力衰竭患者和20例正常人血浆IL-12、IL-18和IFN-γ水平,并分析他们之间的相互关系以及与心力衰竭病情程度的关系。结果心力衰竭患者血浆IL-12、IL-18及IFN-γ水平分别为(181.5±38.5)ng/L、(378.4±185.3)ng/L及(1.86±0.52)ng/L,均显著高于正常人水平[(22.4±4.5)ng/L、(228.5±77.5)ng/L、(0.08±0.03)ng/L](P<0.01),而三者相互呈密切正相关(P<0.05或P<0.01),且3种细胞因子水平在不同心功能的心力衰竭患者间亦有显著性差异(P<0.05或P<0.01),并随心功能的恶化而升高(P<0.05或P<0.01)。结论IL-12、IL-18和IFN-γ可能共同构成一局部网络,并可能参与心力衰竭的发生及发展过程。监测三者的血浆水平可能对判断心力衰竭病情有一定的参考价值。Objective To explore the role of interleukin-12 (IL-12),interleukin-18 (IL-18) and interferon-γ (IFN-γ) in the pathogenesis and development of heart failure (HF) and their interactions.Methods The plasma levels of IL-12,IL-18 and IFN-γ in 36 HF cases and 20 normal controls were detected by enzyme-linked immunoadsordent assay (ELISA) and their relationships with HF as well as their interactions were analyzed.Results In HF patients,the levels of IL-12,IL-18 and IFN-γ were (181.5±38.5) ng/L,(378.4±185.3) ng/L and (1.86±0.52) ng/L,respectively,which were significantly higher than those in normal controls [(22.4±4.5) ng/L, (228.5±77.5) ng/L and (0.08±0.03) ng/L](P<0.01).The three cytokines were positively correlated with each other (P<0.01 for each).There were significant differences in the three cytokines levels among HF patients with different cardiac function (P<0.01 for each),which would elevate with the worsening of cardiac function (P<0.05 or P<0.01).Conclusion The cytokine network constructed by IL-12,IL-18 and IFN-γ may involve in the pathogenesis and development of heart failure,so the monitoring of the cytokines may be helpful for the evaluation of heart failure condition.

关 键 词：心力衰竭 白细胞介素-12 白细胞介素-18 Γ-干扰素 

分 类 号：R541.6[医药卫生—心血管疾病]