依那普利联合美托洛尔长疗程治疗对扩张型心肌病心功能的影响  

EFFECT OF LONG-TERM ENALAPRIL COMBINED METOPROLOL THERAPY ON CARDIAC FUNCTION IN PATIENTS WITH DILATED CARDIOMYOPATHY

作　　者：殷国田[1] 谷高玲[1] 赵国安[1] 丁明伟[1] 

机构地区：[1]新乡医学院第三附属医院心内科,河南省新乡市453003

出　　处：《中国煤炭工业医学杂志》2005年第8期813-814,共2页Chinese Journal of Coal Industry Medicine

摘　　要：目的观察依那普利联合美托洛尔长程治疗对扩张型心肌病(DCM)心力衰竭患者心功能的影响.方法 21例DCM心力衰竭患者在常规治疗基础上,服用依那普利2 .5～5mg/d,心力衰竭改善后,加用美托洛尔,由小剂量开始逐渐增加剂量达100～150mg/d治疗6个月以上 .治疗前、后超声检测每搏量(SV)、心输出量(CO)、左室收缩末内径(LVESD)、左室舒张末内径(LVEDD)、射血分数(EF)、左室短轴缩短率(FS).结果治疗后SV、CO 、LVESD、LVED D、EF较治疗前显著改善(P<0.05).结论长程联用依那普利和美托洛尔能明显改善DCM患者心功能.Objective To observe the effect of long-term enalapril and metoprolol therapy on cardiac function in patients with dilated cardiomyopathy(DCM). Methods 21 cases of DCM with heart failure were regularly treated and enalapril(2.5～5mg daily) was administered. Metoprolol in low-dosage was administered after symptoms of heart failure being improved, and gradually increased to 100～150mg daily for 6 months. Changes of stroke volume(SV),cardiac output(CO),left ventricular dimensions at end-diastole and end-systole(LVEDD,LVESD),ejection fraction(EF),fractional shortening(FS) were examined by echocardiography before and after 6 months therapy. Results After the treatment, there were significant difference in SV,CO,LVESD,LVEDD and EF(P<0.05). Conclusion Long-term enalapril and metoprolol therapy may greatly improve cardiac function in patients with dilated cardiomyopathy.

关 键 词：依那普利 美托洛尔 心肌病 心力衰竭 

分 类 号：R542.2[医药卫生—心血管疾病]