小花五味子中抗HIV活性的木脂素类化合物(英文)  

Anti-HIV Lignans from Schisandra micranthaCJNM

作　　者：李蓉涛[1,2] 韩全斌[1] 郑永唐[3] 王睿睿[3] 杨柳萌[3] 彭丽艳[1] 肖伟烈[1] 孙汉董[1] 

机构地区：[1]中国科学院昆明植物研究所植物化学与西部植物资源可持续利用国家重点实验室 [2]昆明理工大学,昆明650093 [3]中国科学院昆明动物研究所分子免疫药理学实验室

出　　处：《中国天然药物》2005年第4期208-212,i001,共6页

基　　金：国家自然科学基金(No.20402016);国家863计划(2003AA219142);云南省科技攻关项目(2004NG12)资助项目~~

摘　　要：目的:从小花五味子中发现具有抗HIV活性的化学成分。方法:采用多种柱层析分离进行化合物的分离和纯化,通过波谱分析鉴定化合物的结构,化合物的抗HIV 1活性通过对HIV 1感染C8166细胞致细胞病变的抑制试验得到。结果:从小花五味子的茎藤部分分离得到了4个木脂素,分别鉴定为micrantherinA(1),gomisinK3(2),gomisinG(3)和vladinolF(4)。化合物4具有显著的抗HIV 1活性,IC50=3.51μg/mL,选择指数为27.45。结论:化合物1为新的木脂素, 化合物4的抗HIV 1活性值得进一步研究。AIM: To find new natural compounds with anti-HIV activity from Schisandra micrantha. METHORD: The chemical constituents of Schisandra micrantha were isolated by various column chromatographic methods. Their structures were assigned by spectroscopic methods including 2D NMR experiments, and their anti-HIV-1 activities and cytotoxicities were tested by microtiter syncytium formation infectivity assay. RESULT: Four lignans, micrantherin A (1), gomisin K_ 3 (2), gomisin G (3), and vladinol F (4) were isolated from the leaves and stems of Schisandra micrantha. Vladinol F (4) was found to show potent anti-HIV-1 activity with IC_ 50 value of 3.51 μg/mL and a selective index of 27.45. CONCLUSION: Micrantherin A (1) was a new lignan.

关 键 词：五味子科 小花五味子 木脂素 micranthefin A 抗HIV活性 

分 类 号：R284.2[医药卫生—中药学] R965.1[医药卫生—中医学]