血管内皮细胞损伤性疾病患者抗内皮细胞抗体和抗心磷脂抗体检测及其意义  

The role of anti-endothelial cell antibodies and anticardiolipin antibodies in diseases with vascular endothelial cell injuries

作　　者：叶树俊[1] 张葵[1] 陈蕾蕾[1] 毕永春[1] 宋景秋[1] 

机构地区：[1]南京大学医学院附属鼓楼医院,南京210008

出　　处：《临床检验杂志》2005年第4期294-295,共2页Chinese Journal of Clinical Laboratory Science

摘　　要：目的探讨抗内皮细胞抗体(AECA)及抗心磷脂抗体(ACA)与血管内皮细胞损伤性疾病的关系及意义。方法建立ELISA法检测AECA,采用ELISA法测定ACA,分别检测168例血管内皮细胞损伤性疾病患者中2种抗体的水平。结果168例血管内皮细胞损伤性疾病中冠心病、特发性血小板减少性紫癜、溶血性尿毒综合征及妊娠高血压综合征(妊高征)患者的AECA和ACA的阳性率分别为32.9%、22.7%、22.2%、38.9%和38.2%、31.8%、33.3%、44.4%,均显著高于正常对照组。结论AECA和ACA与血管内皮细胞损伤性疾病有一定的相关性。AECA与ACA无相关性。Objective To study the relationship between anti-endothelial cell antibodies (AECA),anticardiolipin antibodies (ACA) and vascular endothelial cell injury diseases and the significance of the autoantibodies.Methods Serum AECA and ACA were detected by ELISA in 168 patients with vascular endothelial cell injury diseases.Result Positive rates of AECA in 168 patients with vascular endothelial cell injury diseases,including coronary heart disease,idiopathic thrombocytopenia purpura,hemolytic uremic syndrome,pregnancy in hypertension,were 32.9%,22.7%,22.2% and 38.9% respectively,and ACA were 38.2%,31.8%,33.3% and 44.4% respectively.They were significantly higher than those of normal controls.Conclusion AECA and ACA are related to the development and progress of vascular endothelial cell injury diseases,AECA and ACA are independent each other.

关 键 词：血管内皮细胞 抗内皮细胞抗体 疾病患者 妊娠高血压综合征(妊高征) 抗体检测 特发性血小板减少性紫癜 其意义 ELISA法检测 溶血性尿毒综合征 损伤性疾病 AECA 抗心磷脂抗体 正常对照组 ACA 相关性 冠心病 阳性率 

分 类 号：R543[医药卫生—心血管疾病] R593.241[医药卫生—内科学]