离子液体促进四氟硼酸铜催化芳醛和乙酸酐合成1,1-二乙酸酯  

Ionic Liquid Promoted Synthesis of 1,1-Diacetates Catalyzed by Copper Tetrafluoroborate from Aromatic Aldehydes and Acetic Anhydride

作　　者：张珉[1] 李毅群[1] 罗慧谋[1] 周美云[1] 

机构地区：[1]暨南大学化学系,广州510632

出　　处：《有机化学》2005年第7期842-845,i004,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20272018)和;广东省自然科学基金(Nos.04010458;021166)资助项目

摘　　要：在室温条件下,离子液体1-正丁基-3-甲基六氟磷酸盐([bmim]PF6)能促进四氟硼酸铜催化一系列芳醛和乙酸酐反应,以83%～97%的产率生成相应的1,1-二乙酸酯.在离子液体[bmim]PF6存在情况下,催化剂活性远远高于无离子液体存在下的活性.催化剂用量仅需0.2mol%就能使反应顺利进行,远远少于文献报道的其它催化剂的用量,反应在3～20min内完成.实验结果表明该法催化剂用量少、产率高、反应时间短、离子液体可重复使用、对环境友好.Ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim,]PF(6)) could efficiently promote synthesis of a variety of 1,1-diacetates catalyzed by copper tetrafluoroborate from corresponding aromatic aldehydes and acetic anhydride at room temperature in 83%similar to 97% yields for 3 similar to 20 min. The activity of the catalyst was shown to be much higher than that without ionic liquid in the same conditions. Use of only 0.2 mol% of the catalyst was sufficient to push the reaction forward and high amounts of the catalyst did not improve the yields to a great extent. The present protocol offered several advantages including low cost of the catalyst, high yields, short reaction time, simple work-up procedure, and moreover, the ionic liquid reusability and benignity to the environment.

关 键 词：离子液体 四氟硼酸 二乙酸酯 乙酸酐 铜催化 芳醛 催化剂用量 合成 六氟磷酸盐 催化剂活性 可重复使用 室温条件 文献报道 反应时间 环境友好 正丁基 产率 

分 类 号：O623.624[理学—有机化学]