丝素蛋白凝胶修饰膜及其理化性能探讨  

Study on the Membranes Modified with Silk Fibroin Gel and Their Physical and Chemical Properties

作　　者：孙东豪[1] 曹雪琴[1] 王文宝[2] 盛伟华[3] 

机构地区：[1]苏州大学材料工程学院,江苏苏州215021 [2]苏州大学测试中心,江苏苏州215006 [3]苏州大学医学院,江苏苏州215006

出　　处：《丝绸》2005年第7期21-23,共3页Journal of Silk

基　　金：国家自然科学基金资助项目(50073014);江苏省丝绸工程重点实验室项目(KJS01028)

摘　　要：用溶液氧化法制备了丝素蛋白凝胶修饰聚氨酯膜,考察了反应前后聚氨酯膜的物理性质和生物相容性。结果表明:修饰后的聚氨酯膜的表面亲水性明显提高,其力学性能和透气性与聚氨酯底膜基本接近,修饰膜克服了纯丝素膜刚而脆的弱点;体外血小板黏附试验和细胞培养实验结果表明了经修饰后,聚氨酯膜的生物相容性明显提高且界面的处理效果是稳定的。Polyurethane(PU)membranes modified with silk fibroin gel(PUS membranes) can be obtained by the redoxreaction in the solution. The physical properties and biological compatibility of different membranes are discussed.The results show that the surface hydrophilicity of PUS membranes is improved, and the mechanical properties and watervapor permeability of PUS membranes are almost the same as those of PU membranes. PUS membranes can overcome rigidand brittle weak of silk fibroin membranes. The results of platelet adhesive test and cell culture test show that PUSmembranes have better biological compatibility and interface stability.

关 键 词：丝素 聚氨酯 修饰 生物相容性 

分 类 号：TS102.54[轻工技术与工程—纺织工程] TB383[轻工技术与工程—纺织科学与工程]