石杉碱甲胃肠道生物粘附片的体外评价  

Evaluation in vitro of Huperzine A Gastrointestinal Bioadhesive Tablets

作　　者：裘建成[1] 孙建绪[1] 高永良[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《科学技术与工程》2005年第14期987-989,共3页Science Technology and Engineering

摘　　要：主要考察了石杉碱甲胃肠道生物粘附片的体外粘附力;采用自制的粘附力测定装置,考察并比较了不同粘附片与大鼠的胃及肠粘膜间粘附力;同时考察了粘附片的体外溶胀百分率。结果表明粘附片与粘膜间的粘附力显著大于普通片,而粘附片与胃粘膜间的粘附力明显小于其与肠粘膜间的粘附力。Studying on bioadhesion of Huperzine A gastrointestinal bioadhesive tablets is the main aim. The bioadhesive force was evaluated by a self-made apparatus, and compared the force between different bioadhesive tablets and gastric or intestinal mucosa. In the same time, the content of swelling and expansion of tablets were also studied. The findings show the bioadhesion force of tablets on gastric mucosa is far smaller than that on intestinal, and the force of bioadhesive tablets is larger than that of the blank.

关 键 词：石杉碱甲 生物粘附 粘附力 溶胀 

分 类 号：R944.9[医药卫生—药剂学]