异丙酚对SIRS患者血前降钙素的影响  

The effects of procalcitonin in SIRS patients sedation with propofol

作　　者：黄瑞云 唐猛 何丽铿 

机构地区：[1]广东省湛江市中心人民医院,湛江524130

出　　处：《广西医学》2005年第6期804-806,共3页Guangxi Medical Journal

摘　　要：目的观察异丙酚对全身炎症反应综合征(SIRS)患者血前降钙素的影响。方法将60例SIRS患者随机分为两组,异丙酚组(n=30)和咪唑安定组(n=30),监测患者入院当天及入院后第3、5、7天的体温、血常规以及外周血中PCT水平,记录患者的急性生理和慢性健康状况评分(APACHEⅡ),并追踪患者的转归。结果异丙酚组除入院当天外,其余各个时点的PCT水平均明显低于咪唑安定组(P<0.05),两组的PCT水平都呈下降趋势,异丙酚组经治疗第3天后的PCT水平与入院时相比均明显降低(P<0.05),而咪唑安定组经治疗第3天后的PCT水平与入院时相比,差异无显著性。两组患者APACHEⅡ评分、白细胞计数、中性粒细胞比例、体温以及死亡率差异均无显著性。结论异丙酚可有效降低SIRS患者外周血中PCT水平。Objective To observer the effects of procalcitonin in SIRS patients sedation with propofol.Methods 60 SIRS patients were randomly divided into propofol group(n=30)and mizodam group(n=30).All the patients received the continuous mornitoring,including body temperature,blood routine and the level of procalitonin in serum.They were also recorded the APACHEⅡ score and the prognosis.Results The procalitonin level in propofol group were dramatically lower than those in mizodam group on every time point excluding in the in-hospital time. The procalitonin level in two groups tended to decrease day by day ,but the procalcitonin level after 3 days treatment in propofol group were markedly lower than that in the first day. There were no difference between two groups in term of APACHEⅡ score,white cell count,propotion of neutrophil,body temperature and mortality.Conclusion Propofol could decrease the procalcitonin level in serum effectively.

关 键 词：异丙酚 SIRS 前降钙素 

分 类 号：R515.3[医药卫生—内科学] R971[医药卫生—临床医学]