“禽福、亿妙灵”对雏鸡IBD疫苗接种后免疫细胞数量的影响  

Changes in Immune Organs of Chicken Vaccinated with IBD Vaccine after Pre-used Immunopotentiator

作　　者：郑世民[1] 贾立军[1] 高雪丽[1] 

机构地区：[1]东北农业大学动物医学学院,黑龙江哈尔滨150030

出　　处：《动物医学进展》2005年第7期69-73,共5页Progress In Veterinary Medicine

基　　金：黑龙江省普通高等学校骨干教师创新能力资助计划项目

摘　　要：分别应用免疫组织化学和组织化学方法对使用免疫增强剂“禽福”和“亿妙灵”的1日龄SPF雏鸡接种IBD疫苗后,对其免疫器官胸腺、法氏囊、脾脏的T细胞和IgG、IgM、IgA抗体生成细胞数量的动态变化进行了较全面系统的研究。结果表明,不论是使用“禽福”,还是“亿妙灵”的雏鸡,接种IBD疫苗后,其上述各项被检指标均不同程度地高于IBD疫苗单独接种雏鸡。其中,“禽福”IBD疫苗接种雏鸡又较“亿妙灵”IBD疫苗接种雏鸡明显增加。表明免疫增强剂“禽福、亿妙灵”能明显提高雏鸡对IBD疫苗的免疫应答,增强IBD疫苗接种雏鸡对vvIBDV攻击的免疫保护率。The dynamics of both T cells and IgG,IgM,IgA antibody-producing cells in immune organs of one-day-old SPF chickens vaccinated with infectious bursal disease(IBD) vaccine after pro-used immunopotentiator(IP)-“Qinfu” or “Immunair” were determined respectively by immunohistochemistry and histochemistry staining. The results showed that the number of IgG,IgM,IgA antibody-producing cells and T cells in immune organs of chicks vaccinated with IBD vaccine after pre-used IP were increased differently degree than alone IBD vaccine vaccination chicks. Meanwhile, the index with mentioned above in pre-used 'Qinfu' chicks vaccinated with IBD vaccine increased significantly compared those pre-used 'Immunair'. The results indicated that IP can significantly improve immune response of SPF chicks to IBD vaccine. The percentage of protection against 'very virulent' infectious bursal disease virus(vvIBDV) of chicks vaccinated with IBD vaccine after pre-used IP were significantly higher than those vaccinated chicks which had not been treated with IPs.

关 键 词：疫苗接种 细胞数量 IBD疫苗 禽 组织化学方法 免疫组织化学 VVIBDV 免疫增强 SPF雏鸡 免疫保护率 免疫器官 动态变化 抗体生成 免疫应答 法氏囊 IgG T细胞 IgM IgA 日龄 脾脏 

分 类 号：S858.31[农业科学—临床兽医学] S852.4[农业科学—兽医学]