复方磷霉素钙水溶性粉处方优化实验  

Experiments on optimization of prescription of compound fosfomyces calcium water soluble powder

作　　者：王春华[1] 毕聪明[1] 王坤[1] 

机构地区：[1]锦州医学院畜牧兽医学院,辽宁锦州121001

出　　处：《中国兽药杂志》2005年第7期34-37,共4页Chinese Journal of Veterinary Drug

摘　　要：为了优选磷霉素钙复方制剂,采用体外药物最小抑菌浓度测定法,测定了磷霉素钙与甲氧啶(TMP)、丁胺卡那霉素、恩诺沙星、庆大霉素、头孢噻肟钠、多西环素、氟甲砜霉素联合使用对大肠杆菌作用的协同指数。结果表明磷霉素钙与TMP的协同关系最好,协同指数为0.281,制剂中磷霉素钙与TMP的含量分别为5%和1%为最佳。To optimize prescription of compound fosfomyces calcium, the assay method of minimal inhibitory concentration in vitro is used. The fractional inhibitory concentration(FIC) of fosfomyces calcium combined with TMP, amikacin, enrofloxacin, gentamycin, cefalotin sodium, doxycycline and florfenicol against E.coli were determined respectively. The results showed that the synergism of fosfomyces calcium and TMP is the best. The FIC is 0.281. The optimum compatible concentration of fosfomyces calcium and TMP are 5% and 1%.

关 键 词：磷霉素 优化实验 水溶性粉 钙 处方 最小抑菌浓度 丁胺卡那霉素 协同指数 头孢噻肟钠 氟甲砜霉素 复方制剂 恩诺沙星 庆大霉素 多西环素 大肠杆菌 联合使用 协同关系 TMP 测定法 

分 类 号：S859.79[农业科学—临床兽医学] TQ465[农业科学—兽医学]