流动注射电化学发光分析法测定左旋多巴的研究  

Study on the Determination of Levodopa by Flow-Injection Electrogenerated Chemiluminescence

作　　者：马红燕[1] 郑行望[2] 章竹君[2] 

机构地区：[1]延安大学化学与化工学院,陕西延安716000 [2]陕西师范大学化学与材料科学学院,陕西西安710062

出　　处：《分析测试学报》2005年第4期58-60,共3页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目(397301610);陕西省教育厅科研基金资助项目(04JK305)

摘　　要：基于左旋多巴对鲁米诺在铂电极上弱的电氧化发光信号的强增敏作用与流动注射技术的结合,建立了一种测定左旋多巴的电化学发光分析新方法.该法测定左旋多巴的检出限为2.0×10-10g/mL,线性范围为4.0×10-10～2.0×10-6g/mL,相对标准偏差为2.0%(n=11).该法简单、快速、灵敏,已成功地用于样品中左旋多巴的测定.Anewflowinjectionelectrogenerated chemiluminescence(ECL)method forthe determination oflev-odopa was developed.It is based on the sensitizing effect of levodopa on the weak ECLsignal of electrochemi-cal oxidation of luminol on the platinum flake electrode in the medium of0.1mol/L Na 2 CO 3 -NaHCO 3 .The experimental conditions influencingthe ECLintensitywere investigated and optimized.Underthe optimumcon-ditions,the ECL response is in the range of4.0×10 -10 -2.0×10 -6 g/mL levodopa with a detection limit of2.0×10 -10 g/mL.The relative standard deviation is2.0%.This method was used to determine levodopa in pharmaceuticals samples with satisfactory results.

关 键 词：电化学发光分析 左旋多巴 鲁米诺 流动注射分析 

分 类 号：O657.1[理学—分析化学] R971.2[理学—化学]