石菖蒲挥发油及β-细辛醚对心血管的保护作用  

Protective Effects of Volatile Oil of Acorus tatarinowii Schott and β - Asarone on Cardiovascular System

作　　者：吴启端[1] 方永奇[1] 陈奕芝[1] 匡忠生[1] 王淑英[1] 何玉萍[1] 

机构地区：[1]广州中医药大学第一临床医学院实验中心,广州510405

出　　处：《中药新药与临床药理》2005年第4期244-247,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：广东省教育厅资助课题(编号Z02012);广东省中医药管理局资助课题(编号2040018)。

摘　　要：目的研究石菖蒲挥发油、β-细辛醚对心血管的保护作用。方法采用动脉粥样硬化试验、高粘血症试验以及心肌缺血试验,观察石菖蒲挥发油、β-细辛醚对动脉粥样硬化大鼠血脂、高粘血症大鼠血液流变学、异丙肾上腺素致心肌缺血大鼠内皮素(ET)、一氧化氮(NO)及心肌组织坏死的影响。结果石菖蒲挥发油、β-细辛醚能明显降低动脉粥样硬化大鼠血脂(CHOL及LDL-C);能改善高粘血症大鼠的血液流变性;能降低心肌缺血大鼠ET水平、提高NO的含量,降低心肌组织损伤程度和坏死率。结论石菖蒲挥发油、β-细辛醚对心血管有明显的保护作用。Objective To study the protective effects of volatile oil of Acorus tatarinowii Schott and β - asarone on cardiovascular system. Methods The rat models of atherosclerosis and hyperviscocity as well as acute myocardial ischemia were established. The effects of volatile oil of Acorus tatarinowii Schott and β - asarone were observed on the blood lipid level and the atherosclerotic degree in atherosclerosis rats, hemorheology in hyperviscocity rats and endothelin (ET) level, nitric- oxide (NO) level and myocardial damage in rats with isoproterenol- induced myocardial ischemia. Results Volatile oil of Acorus tatarinowii Schott and β - asarone could singnificantly decrease the levels of cholesterol and low- density lipoprotein cholesterol and the degree of atherosclerotic lesion in atherosclerosis rats, improve the hemorheology in hyperviscocity rats, and decrease ET level, increase NO level and reduce myocardial damage and infarction rate in rats with myocardial ischemia. Conclusion Volatile oil of Acorus tatarinowii Schott and β - asarone have certain protective effects on cardiovascular system.

关 键 词：石菖蒲 Β-细辛醚 心血管 血脂 血液流变学 内皮素 一氧化氮 

分 类 号：R285.5[医药卫生—中药学]