胃肠舒胶囊抗实验性胃溃疡作用的研究  

Effect of Weichangshu Capsule on Experimental Gastric Ulcer

作　　者：林吉[1] 荣向路[2] 黄萍[2] 谢友良[1] 苏子仁[1] 赵学军[1] 

机构地区：[1]广州中医药大学新药开发研究中心,广州510405 [2]广州中医药大学中药学院,广州510405

出　　处：《中药新药与临床药理》2005年第4期256-259,共4页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的研究胃肠舒胶囊抗SD大鼠胃溃疡及抗胃粘膜损伤的作用。方法采用幽门结扎法、水浸拘束法、皮下注射消炎痛等方法致大鼠胃溃疡,盐酸-乙醇致大鼠急性胃粘膜损伤,观察胃肠舒胶囊抗胃溃疡和胃粘膜保护实验。结果胃肠舒胶囊对大鼠应激性胃溃疡、消炎痛性胃溃疡和盐酸-乙醇所致大鼠急性胃粘膜损伤有明显的抑制作用。胃肠舒胶囊还有抑制大鼠胃液分泌和提高胃蛋白酶活性作用。结论胃肠舒胶囊具有抗实验性胃溃疡的作用。Objective To observe the effect of Weichangshu Capsule (WCSC) in inhibiting experimental gastric ulcer and the damage of gastric mucosa in SD rats. Methods The experimental gastric ulcer rat models were established by ligation of pylorus, water immersing method and subcutaneous injection of indometacin, and rat models with acute damage of gastric mucosa were induced by hydrochloric acid- ethanol (HAE).Then the effect of WCSC in inhibiting experimental gastric ulcer and the damage of gastric mucosa in SD rats were observed. Results WCSC had obviously inhibitory effects on stress gastric ulcer, indometacin- induced gastric ulcer and HAE- induced acute damage of gastric mucosa. WCSC also inhibited the secretion of gastric juice and increased pepsase activity. Conclusion WCSC has counteraction on experimental gastric ulcer.

关 键 词：胃肠舒胶囊 胃溃疡 药效学 

分 类 号：R285.5[医药卫生—中药学]