虎金丸对肝纤维化大鼠Ⅳ型胶原表达的影响  

Effect of Hujin Pill on Express of Collagen Ⅳ in Liver Fibrosis Rats

作　　者：吴庆光[1] 刘明平[1] 赵珍东[1] 

机构地区：[1]广州中医药大学,广东广州510405

出　　处：《中国实验方剂学杂志》2005年第4期45-47,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省中医药局项目(98328)

摘　　要：目的:观察虎金丸对肝纤维化大鼠胶原增生及Ⅳ型胶原(ⅣC)表达的影响。方法:以CCl4复制肝纤维化大鼠动物模型,采用VG染色、免疫组化技术观察虎金丸对肝纤维化胶原增生及ⅣC表达的影响。结果:CCl4肝纤维化大鼠模型肝组织胶原纤维明显增生、ⅣC表达较正常对照组明显增强,虎金丸能抑制肝纤维化大鼠胶原增生及ⅣC在肝纤维化大鼠肝组织中的表达。结论:虎金丸有抗肝纤维化作用。Objective:To observe the effect of Hujin Pill on fibrous hyperplasia and express of collagen Ⅳ in liver fibrosis rats.Methods:Model of liver fibrosis were induced by subcutaneous injection of CCl4 and treated with Hujin Pill.The changes of fibrous hyperplasia and express of collagen Ⅳ of the rats' liver were observed with Van Gieson stain and immunohistochemistry.Results:The fibrous hyperplasia of liver and the express of collagen Ⅳ in liver fibrosis rats' model had been markedly increased than that of control group.However,Hujin Pill could restrain fibrous hyperplasia and express of collagen Ⅳ in liver fibrosis rats.Conclusion:Hujin Pill was effective in treatment of CCl4-induced liver fibrosis.

关 键 词：虎金丸 肝纤维化 Ⅳ型胶原 

分 类 号：R285.5[医药卫生—中药学]