西安市人疱疹病毒6型血清流行病学调查  

Seroepidemiologic Study on Human Herpesvirus 6 Among Children and Adults in Xi'an

作　　者：刘军连[1] 徐志凯[2] 王德堂[3] 王红英[3] 许东亮[4] 姚堃[5] 

机构地区：[1]解放军306医院皮肤科,北京100101 [2]第四军医大学微生物学教研室 [3]第四军医大学西京医院妇产科 [4]第四军医大学西京医院儿科 [5]南京大学医学院微生物学教研室

出　　处：《实用预防医学》2005年第4期729-730,共2页Practical Preventive Medicine

基　　金：国家自然科学基金(39270034);江苏省自然科学基金(BJ93096)

摘　　要：目的了解西安市区不同人群人疱疹病毒6型(HHV-6)的感染和免疫水平状况。方法采用间接免疫荧光试验方法检测儿童、成人和育龄妇女血清HHV-6IgG抗体。结果6个月～2岁幼儿的HHV-6抗体阳性率和几何平均滴度(GMT)分别为92.9%和1:152,高于其它年龄段的儿童和成人(P<0.05)。116份育龄妇女血清HHV-6抗体阳性率为72.4%,GMT为1:61;在孕妇和正常妇女之间,以及不同孕期的孕妇之间,HHV-6IgG抗体的阳性率和GMT均无差异(P>0.05)。结论HHV-6在不同人群中均有较高的感染率;HHV-6感染多可能发生在婴幼儿期,以水平传播为主;妇女妊娠期间无HHV-6的活化。Objective To ascertain the immune level and infection status of human herpesvirus 6 (HHV-6) among children and adults from urban areas of Xi'an. Methods Serum HHV-6 IgG antibody was detected and analyzed with indirect immunofluorescence assay. Results Among children aged from 6 months to 2 years old, the positive rate of antibody titers against HHV-6 was 92.9% and the geometric mean titer(GMT) was 1:152, which were higher than that of the other children age groups and adults(P<0.05). Serum samples from 116 pregnant women and age matched controls were tested for HHV-6 IgG antibody levels, the positive rate was 72.4% and the GMT was 1:61; no significant difference was observed between them(P>0.05). Conclusion Seroepidemiology evidence indicates that HHV-6 infection is very common among children and healthy adults and it likely to peak among children from 6 months to 2 years old. The results also strongly implicate the horizontal transmission is a common mode of transmission, but the reactivation of HHV-6 might not occur during pregnancy.

关 键 词：人疱疹病毒6型 血清流行病学 西安市 间接免疫荧光试验 

分 类 号：R373.1[医药卫生—病原生物学]