川芎嗪辅助治疗对原发性肾病综合征血流状态的影响  

Effects of Flushing Dose of Ligustrazine on Haemorheology in Nephrotic Syndrome

作　　者：张琼 易铁钢[2] 高晓洁[3] 

机构地区：[1]广东省深圳市福田区梅林医院,深圳518101 [2]广东省深圳市中医院,深圳518033 [3]广东省深圳市儿童医院,深圳518101

出　　处：《中国中西医结合肾病杂志》2005年第7期393-394,共2页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：广东省中医药管理局基金资助项目(No.103125)

摘　　要：目的观察川芎嗪辅助治疗对原发性肾病综合征患者血流状态的影响。方法对照组常规激素(泼尼松1mg·kg-1·d-1)治疗;治疗组在常规激素治疗的基础上给予川芎嗪(400～600mg·次-1·d-1)加入5%葡萄糖溶液500ml中静脉滴注,14d为1疗程。观察两组在治疗前后血液流变学、血脂及肾功能等指标的变化。结果治疗组全血比黏度(高切及低切)、血浆比黏度、红细胞聚集指数、血沉、血脂及肾功能等指标均比对照组有显著改善(P<0.05～0.01)。结论川芎嗪辅助治疗原发性肾病综合征可明显改善其高血黏度、高血凝滞、高血脂症及肾功能。Objective:To study the effects of Ligustrazine on blood rheology in Nephrotic syndrome.Methods:Nephrotic syndrome patients were randomly divided into two groups. Based on the regular prednisone therapy, the treated group was given Ligustrazine (400～600 mg/d), totally for 14 days. Haemorheology indices, Fibrinogen and Cholesterol were observed.Results:Flushing dose of Ligustrazine treatment significantly reduced the haemorheological indices, Fibrinogen and Cholesterol in Nephrotic syndrome patients(P<0.05～0.01).Conclusion:Flushing dose of Ligustrazine treatment may ameliorate the blood state with 'high viscosity','high aggregation'and 'high concentration' in patients with Nephrotic syndrome.

关 键 词：原发性肾病综合征 川芎嗪辅助治疗 血流状态 5%葡萄糖溶液 红细胞聚集指数 血液流变学 全血比黏度 血浆比黏度 肾功能 静脉滴注 激素治疗 治疗前后 0.05 高血黏度 高血脂症 对照组 治疗组 泼尼松 高血凝 指标 

分 类 号：R692[医药卫生—泌尿科学] R277.733.3[医药卫生—外科学]