浅表性膀胱肿瘤对化疗药物的敏感性研究  

The chemosensitivity study of superficial bladder cancer

作　　者：李东[1] 袁静[2] 黄旭元[1] 黄翼然[1] 王益鑫[1] 

机构地区：[1]上海第二医科大学附属仁济医院泌尿外科,上海200001 [2]上海第二医科大学附属仁济医院药剂科

出　　处：《临床泌尿外科杂志》2005年第7期407-409,共3页Journal of Clinical Urology

摘　　要：目的:探讨敏感化疗药物预防浅表性膀胱癌术后复发的作用。方法:对30例表浅性膀胱癌体外原代细胞培养,用表阿霉素、羟基喜树碱、吡柔比星、丝裂霉素和盐酸米托蒽醌进行MTT法药物敏感实验(敏感实验组),用最敏感药物行膀胱灌注;同期选择30例患者用吡柔比星灌注作为对照(对照组)。结果:敏感实验组17例对吡柔比星最敏感,6例对盐酸米托蒽醌最敏感,3例对丝裂霉素最敏感,1例对羟基喜树碱最敏感,1例对表阿霉素最敏感,2例对5种化疗药物都不敏感。28例患者分别选择最敏感药物灌注后随访2年,2例复发(7.1%)。对照组吡柔比星灌注后随访2年,有8例复发(26.7%)。两组比较差异有统计学意义(P<0.05)。结论:5种化疗药物对膀胱肿瘤的体外细胞毒作用不同,其中吡柔比星的抑制作用最强。根据药物敏感实验对浅表性膀胱肿瘤行灌注治疗,对预防肿瘤复发有较好效果。Objective:To study the effectiveness of intravesical sensitive chemicals treatment to prevent recurrence after operation.Methods:The chemosensitivity test of 30 superficial bladder cancer samples to Pirarubicin , Hydroxycamptothecin, Doxorubicin, Mitomycin C and Mitoxantrone Hydrochloride was studied by means of in vitro primary cell culture and MTT assay. The test group received intravesical instillation of the most sensitive chemicals based on the chemosensitivity test. The control 30 cases had intravesical instillation with THP.Results:The cases to the most sensitive chemicals were 17 for THP,6 for MTT,3 for MMC,1 for OPT,1 for EPI. Two cases were not sensitive to all chemicals. Followed up 2 years ,the recurrence rate was (7.1)% in the test group and significantly lower than (26.7)% in the control group (P<(0.05)).Conclusions:The inhibitory rates to superficial bladder cancer were not different in five drugs,among them the THP was the most strong. According to chemosensitivity test, intravesical instillation the most sensitive chemicals provided effective prophylaxis to superficial bladder cancer.

关 键 词：抗肿瘤药物 膀胱肿瘤 化学疗法 

分 类 号：R695[医药卫生—泌尿科学]