肥胖儿童T淋巴细胞亚群的功能评估  

Functional Evaluation of Immunologically Competent Cell in Obese Children and Adolescents

作　　者：汤庆娅[1] 冯一[1] 陶晔璇[2] 费延文[1] 蔡威[1] 

机构地区：[1]上海第二医科大学附属新华医院上海儿童医学中心临床营养中心 [2]上海市儿科医学研究所营养研究室

出　　处：《中国临床营养杂志》2005年第3期154-156,共3页Chinese Journal of Clinical Nutrition

摘　　要：目的了解肥胖儿童的细胞免疫功能状态。方法2002年4月～2003年10月,共采集我院肥胖专科门诊儿童和青少年的单纯性肥胖患儿47例,其中男30例,女17例,平均年龄(11.4±2.2)岁;同期随机抽取37名正常体重学生的健康自愿者作为对照组,其中男16例,女21例,平均年龄(13.4±1.0)岁。采集肘部静脉血,采用流式细胞仪进行T淋巴细胞的亚群分析。结果肥胖组的T淋巴细胞亚群CD3+、CD4+、CD8+和CD4+/CD8+与对照组相比,差异均无显著性(均P>0.05);且CD3+、CD4+、CD8+和CD4+/CD8+与肥胖程度无相关性(r分别为-0.012、-0.102、0.139、-0.103,均P>0.1)。正常组CD3+、CD4+、CD8+和CD4+/CD8+与体重也无相关性(r分别为-0.223、-0.076、-0.190、-0.072,均P>0.1)。结论肥胖患儿T淋巴细胞亚群的免疫功能无减退现象。Objective To understand the function of immunologically competent cell in obese children and adolescents. Methods The plasms T- lymphocyte subsets of 84 children and adolescents(47 obese and 37 normal, 46 boys and 38 girls) were examined, including CD3+, CD4+, and CD8+ T-lymphocyte cells. Results The plasma T-lymphocyte subsets count percent of 47 obese children and adolescents had not statistical significance compare with the normal group(P > 0.05), and the value of CD3+, CD4+,CD8+ and the rate of CD4+/CD8+ apart were not correlated with the obesity degree(r = -0.012, -0.102, 0.139, and -0.103, P > 0.1). Conclusion No functional impairment of T-lymphocytes immunity exists in obese children and adolescents.

关 键 词：肥胖 儿童 T细胞亚群 

分 类 号：R723.14[医药卫生—儿科]