1型糖尿病患者血清中抗IA-2与抗GAD_(65)抗体的比较  

Comparison between the Level of Serum Anti-IA-2 Antibody and Anti-GAD Antibody in Type Ⅰ Diabetic Patients

作　　者：张瑞[1] 郭刚[1] 梁东春[1] 张镜宇[1] 

机构地区：[1]天津医科大学,300070

出　　处：《天津医药》2005年第7期401-402,共2页Tianjin Medical Journal

基　　金：天津市21世纪自然科学基金(项目编号:973706611)

摘　　要：目的:研究成人1型糖尿病患者血清中抗IA-2抗体和抗GAD65抗体的水平并进行分析。方法:用ELISA法检测了48例20～45岁,病程小于2年的1型糖尿病患者组血清中的IgG型抗IA-2抗体和抗GAD65抗体,并以110例正常人血清作对照组。结果:患者组血清中抗IA-2抗体和抗GAD65抗体的水平与对照组差别均有统计学意义,而且患者组血清中抗IA-2抗体较抗GAD65抗体有更高的阳性率。结论:成人新发1型糖尿病患者血清中IgG型抗IA-2抗体和抗GAD65抗体均有不同程度明显升高,而且对两者进行联合检测会更有助于临床上1型糖尿病的早期诊断。Objective To study the level of serum anti-IA-2 antibody and to compare it with that of anti-GAD antibody in type I diabetic patients. Methods Using ELISA method the serum levels of anti-IA-2 IgG and anti-GAD65 antibody were detected in 48 type 1 diabetic patients aged from 20 to 45.These patients had been diagnosed diabetes in the recent 2 years. At the same time the antibody in 110 healthy people was also detected as control. Results There was significant difference in the level of serum anti-IA-2 IgG between the patients and controls. Compared with anti-GAD65 anti-IA-2 showed higher positive rate. Conclusion Anti-IA-2 IgG was significanfly elevated in type 1 diabetic patients and showed higher positive rate than anti-GAD65 IgG. Analysis of anti-IA-2 antibody and anti-GAD antibody would help with the early diagnosis and classification of type 1 diabetes.

关 键 词：GAD65 糖尿病患者 IA-2 抗体 ELISA法检测 IGG型 1型糖尿病 不同程度 早期诊断 联合检测 对照组 人血清 统计学 阳性率 水平 成人 

分 类 号：R587.2[医药卫生—内分泌] R587.1[医药卫生—内科学]