纤溶和凝血因子在急性肺血栓栓塞症发病机制中的作用  

Study on Plasma Concentration of Coagulation and Fibrinolytic Parameters in Acute Pulmonary Thromboembolism

作　　者：陈永利[1] 张敬霞[2] 王佩显[1] 李京艳[1] 毕研永[1] 袁志明[1] 

机构地区：[1]天津医科大学总医院内科,300052 [2]天津市胸科医院心内科

出　　处：《天津医药》2005年第7期403-404,共2页Tianjin Medical Journal

基　　金：天津市自然科学基金重点资助项目(项目编号:013609011)

摘　　要：目的:测定急性肺血栓栓塞症(APT)患者凝血和纤溶因子的血浆含量,探讨其在发病机制中的作用。方法:对44例APT患者(APT组)和56例健康查体者(对照组)应用酶联免疫吸附双抗体夹心法(ELISA法)定量测定血浆tPA、PAI-1、PC、FPS和vWF∶Ag抗原水平。结果:与对照组相比,APT组tPA、PAI-1和vWF∶Ag血浆含量水平较高,FPS水平较低,且差别有显著统计学意义。结论:PAI-1及vWF∶Ag产生、释放增多和FPS血浆含量减低在急性肺血栓栓塞症的发病机制中具有重要作用。Objective To explore the changes and the roles of coagulation and fibrinolytic parameters in acute pulmonary thromboembolism APT. Methods The antigen levels of tPA,PAI-1,PC,FPS and vWF∶Ag were quantified by a commercially available enzyme-linked immunosorbent assay ELISA respectively in various therapytic periods of 44 APT cases and 56 healthy control cases. Results APT patients had higher levels of tPA,PAI-1 and vWF antigen and lower levels of FPS before the starting of therapy than thoes of healthy-control group. Conclusions Increased PAI-1 and vWF antigen levels and decreased FPS level in plasma may contribute to the incidence of APT.

关 键 词：急性肺血栓栓塞症 发病机制 凝血因子 酶联免疫吸附双抗体夹心法 VWF:AG PAI-1 血浆含量 ELISA法 血浆TPA FPS 纤溶因子 定量测定 健康查体 抗原水平 对照组 APT 统计学 患者 

分 类 号：R563.5[医药卫生—呼吸系统] R446.11[医药卫生—内科学]