非离子型L-赖氨酸长链酯-双EDTA酰胺钆配合物的合成与弛豫效能  

Synthesis and Relaxivity of Neutral Dimeric Gd(Ⅲ) Complexes Derived from L-Lysine with Long Chain Alkyl Esters

作　　者：周锦兰[1] 万福贤[1] 俞开潮[1,2] 丁尚武[2] 杨年华[3] 叶朝辉[1,3] 

机构地区：[1]华中科技大学化学系 [2]高雄中山大学化学系与纳米科技中心,高雄804-24 [3]波谱与原子分子物理国家重点实验室,中国科学院武汉物理与数学研究所

出　　处：《无机化学学报》2005年第8期1237-1241,共5页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.20275011;10234070);台湾教育部"大学追求卓越计划"(No.A-92-N-FA01-2-4-5);波谱与原子分子物理国家重点实验室基金(No.T012045)资助项目。

摘　　要：Four novel ester-amino ligands were synthesized by bis-acylation of octadecanyl, hexadecanyl, tetradecanyl and dedecanyl L-lysinate with ethylenediaminetetraacetic acid mono-anhydride (EDTA-MA), respectively. The corresponding neutral dimeric Gd(Ⅲ) complexes were gained by reacting these ligands with GdCl3·6H2O. All ligands and complexes were characterized by FTIR, 1H NMR and elemental analysis. The longitunal relaxation time (T1) was measured, and their stability were investigated by competition with Ca2+ and EDTA. The results indicate that the relaxivity of these netral binuclear Gd(Ⅲ) complexes are higher than that of Gd-DTPA.Four novel ester-amino ligands were synthesized by bis-acylation of octadecanyl, hexadecanyl, tetradecanyl and dedecanyl L-lysinate with ethylenediaminetetraacetic acid mono-anhydride (EDTA-MA), respectively. The corresponding neutral dimeric Gd(Ⅲ) complexes were gained by reacting these ligands with GdCl3·6H2O. All ligands and complexes were characterized by FTIR, 1H NMR and elemental analysis. The longitunal relaxation time (T1) was measured, and their stability were investigated by competition with Ca2+ and EDTA. The results indicate that the relaxivity of these netral binuclear Gd(Ⅲ) complexes are higher than that of Gd-DTPA.

关 键 词：非离子造影剂 L-赖氨酸长链烷基酯 双EDTA酰胺 双核钆配合物 弛豫效能 

分 类 号：O614.339[理学—无机化学]