大量骨溶解症患者头发中微量元素的初步研究  

The Preliminary Study of Trace Elements in the Hair of Patient With Massive Osteolysis

作　　者：曹晓娟[1] 陈明[1] 吕肖锋[2] 陈红军[1] 李艳玲[2] 武晋晓[2] 

机构地区：[1]国家地质实验测试中心,北京100037 [2]北京军区总医院,北京100700

出　　处：《环境与健康杂志》2005年第4期267-268,共2页Journal of Environment and Health

基　　金："863"计划资助项目(2001AA135120);"973"计划资助项目(G1999045708);国家自然科学基金资助项目(49973015);法国国家科研中心国际合作项目(PICS2039)。

摘　　要：目的通过检测大量骨溶解症患者头发中微量元素,探索大量骨溶解症的发病病因,为该病的防治提供科学依据。方法取新疆某大量骨溶解症患者枕际发,通过电感耦合等离子体光谱和电感耦合等离子体质谱法检测其发中的14种元素。结果患者发铬含量0.5μg/g,为正常儿童的0.11～0.22倍;发锌含量40μg/g,为正常儿童的0.27～0.33倍。发钾含量3457μg/g,为正常人发中含量的115.23～345.7倍,发钠含量3757μg/g为正常人发中含量的34.64倍。钾钠比1.254,是正常值的3～10倍。结论大量骨溶解症很可能跟患者生存的外部环境以及饮食习惯有关。Objective To have knowledge of the exact cause of massive osteolysis. Methods Hair of patients from Xinjiang province was collected and 14 trace elements were determined by inductively coupled plasma mass spectrometryICP-MS. Results Trace elements imbalance in the body of patients was disturbed. Chromium and zinc which are benefit to the growth of the bones were only 0.5 μg/g and 40 μg/g respectively that were much lower compared with the healthy persons cadmium was much higher than the limit level in healthy person. Moreover the quantity and ratio of potassium and sodium in the patients were obvious abnormal. Conclusion According to the result of the present paper may be the environmental and dietary factors play an important role in pathogenesis of this disease.

关 键 词：钠 钾 大量骨溶解症 头发 微量元素 

分 类 号：R181.3[医药卫生—流行病学]