G_（9315）抗致癌作用研究  

Anti-promoting and Anti-mutagenic Actions of G_(9315)

作　　者：傅乃武[1] 刘朝阳[1] 张如意[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤研究所,北京医科大学药学院

出　　处：《中国医学科学院学报》1995年第5期349-352,共4页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金

摘　　要：Ｇ_（９３１５）是从胀果甘草中提取的含有６个黄酮体的复合物，１ｍｇ剂量显著抑制巴豆油诱发的小鼠耳部水肿，２ｍｇ剂量明显抑制二甲基苯蒽（ＤＭＢＡ）合并巴豆油诱发的小鼠皮肤乳头瘤的生成，表现出较强的抗促癌作用。小鼠口服Ｇ_（９３１５）０．５ｇ／ｋｇ（ｐｏ×７），明显对抗环磷酰胺７０ｍｇ／ｋｇ（ｉｐ×１）诱发的骨髓细胞微核增多。Ｇ_（９３１５）２０～４０μｇ／ｍｌ显著抑制ＴＰＡ促进的３２Ｐｉ参入ＨｅＬａ细胞的磷脂部分。G9315,a complex extracted from Glycyrrhizae inflata Bat(Ⅲ),consists of 6 flavonoids with significant antioxidant effects.At 1 mg dose it inhibited the mouse ear edema induced by croton oil,and showed strong anti-promoting effects on two-stage carcinogenesis in mouse skin induced by DMBA plus croton oil. The TPA enhanced 32Pi-incorporation into phospholipid fraction in HeLa cells was inhibited ,and the micronuclei in mouse bone marrow cells induced by cytoxan was also depressed.

关 键 词：G9315 甘草 抗促癌作用 实验药理学 

分 类 号：R965.2[医药卫生—药理学]