超声直视下冠心病患者颈动脉斑块与hs-CRP、sICAM-1的相关性研究  

Study on Correlation Between High Sensitive-C Reactive Protein、Soluble Intercellular Adhesion Molecule-1 and Carotid Atherosclerotic Plaque in Coronary Heart Disease Patients

作　　者：朱文晖[1] 张梦玺[1] 肖际东[1] 张志辉[1] 曹宇[1] 欧阳茂[1] 

机构地区：[1]中南大学湘雅三医院超声科,湖南长沙410013

出　　处：《医学临床研究》2005年第7期865-867,870,共4页Journal of Clinical Research

基　　金：湖南省自然科学基金资助项目(项目编号03JJY4043)

摘　　要：【目的】研究不同程度冠状动脉病变患者颈动脉内-中膜厚度(IMT)及斑块指数与血清高敏C反应蛋白(hsCRP),可溶性细胞间粘附分子1(sICAM1)的相关性。【方法】对82例入院接受冠状动脉造影的病人进行颈动脉超声检查,根据冠状动脉造影结果分为正常冠状动脉组,冠状动脉单支病变组,及冠状动脉多支病变组(双支或三支病变患者)。采用高频超声探测双侧颈动脉IMT和斑块指数,以及测定血清hsCRP,sICAM1含量。【结果】①冠状动脉多支病变组IMT,软斑指数,硬斑指数及总斑块指数明显高于正常组和IMT,软斑指数,总斑块指数明显高于冠状动脉单支病变组;冠状动脉多支病变组血清hsCRP,sICAM1含量亦明显高于正常组及冠状动脉单支病变组。②血清hsCRP和血清sICAM1与IMT,软斑指数,硬斑指数及总斑块指数均呈正相关。【结论】通过颈动脉超声检测,可以初步预测冠状动脉病变程度与颈动脉粥样斑块及炎性因子的关系。[Objective]To detect the intima-media thickness(IMT),plaque index of the carotid artery in patients with various severity of coronary disease and the relationship between high sensitive-C reactive protein(hs-CRP)、soluble intercellular adhesion molecule-1(sICAM-1) and the plaque indices.[Methods]Coronary angiography was performed in 82 patients whose carotid arteries were examined with high frequency Ultrasonography.They were divided into a group with normal coronary angiography and another group with coronary artery lesions.The latter group included one-vessel disease group and multi-vessel (included two-vessel or three-vessel)disease group.The intima-media thickness(IMT) and plaque indices of carotid artery as demonstrated by high frequency ultrasonography,in addition to the measurement of hs-CRP and sICAM-1 levels.[Results]①Compared with normal group,IMT,soft and hard plaque indices,total plaque index in multi-vessel coronary disease group were significantly increased.Compared with one-vessel coronary disease group, IMT,soft and hard plaque indices,total plaque index in multi-vessel coronary disease group were also significantly increased.Hs-CRP and sICAM-1 levels in multi-vessel coronary disease group were significantly increased as compared with those in one-vessel coronary disease group and normal group.②Hs-CRP and sICAM-1 levels had positive relationship with the IMT,soft and hard plaque indices,total plaque index in the carotid artery,respectively.[Conclusion]The relationship among the coronary artery lesion,carotid atherosclerotic plaque,inflammatory factor can be predicted by examining the carotid artery by ultrasonography.

关 键 词：冠状动脉疾病/超声检查 颈动脉 C反应蛋白质 胞间粘附分子1 

分 类 号：R543.3[医药卫生—心血管疾病]