DTPA、EDTA氨基安替比林衍生物的合成及其金属配合物的弛豫性能研究  

Synthesis ,relaxivity of Gd(Ⅲ) ,Fe(Ⅲ) and Mn(Ⅱ) com-plexes with 4-amino-antipyrine derivatives of DTPAand ED-TA

作　　者：罗丽[1] 石森炎[1] 孙伟[1] 常建华[1] 

机构地区：[1]西北大学化学系,陕西西安710069

出　　处：《化学试剂》2005年第7期389-391,394,共4页Chemical Reagents

摘　　要：二乙三胺五乙酸(DTPA)酸酐和乙二胺四乙酸(EDTA)酸酐与4-氨基安替比林(4-AAP)反应,合成了含氨基安替比林的配体DTPA-4-AAP和EDTA-4-AAP,并分别合成了与Gd(Ⅲ)、Fe(Ⅲ)、Mn(Ⅱ)的配合物,配体和配合物用IR1、HNMR与元素分析做了结构表征。测定了配合物的体外弛豫效率,获得了较好的结果。Two novel ligands of DTPA and EDTA 4-APP derivatives have been respectively synthesized by reaction of DTPA-dianhydride and EDTA-dianhydride with 4-amino-antipyrine.Their complexes of gadolinum,manganese and iron were prepared.The structures of the two ligands and their complexes were analyzed by IR,(()~1HNMR) and elemental analysis.The NMR T_1 relaxivities(R_i) of complexes have been investigated and the results showed that the Gd() complexes possessed the precondition to be contrast agents for magnetic resonance imaging.

关 键 词：磁共振成像造影剂 二乙三胺五乙酸(DTPA) 乙二胺四乙酸(EDTA) 4-氨基安替比林(4-AAP) 弛豫效率 

分 类 号：O623.626[理学—有机化学]