3-醛基吲哚-4-甲酸乙酯的合成  

Synthesis of ethyl 3-formylindole-4-carboxylate

作　　者：葛裕华[1] 吴亚明[1] 薛忠俊[1] 

机构地区：[1]东南大学化学化工系,江苏南京210096

出　　处：《化学试剂》2005年第7期443-444,共2页Chemical Reagents

摘　　要：以2-甲基-3-硝基苯甲酸为起始原料,酸催化酯化得2-甲基-3-硝基苯甲酸乙酯(1),1与N,N-二甲基甲酰胺二乙基缩醛缩合得β-哌啶基-2-乙氧羰基-6-硝基苯乙烯(2),然后还原环化得吲哚-4-甲酸乙酯(3),3再经Vilsmeier-Hacck反应制得标题化合物,反应总收率达57%。产物的结构经IR和1HNMR得到了确证,纯度为99.2%。The synthetic method for a new compound ethyl 3-formylindole-4-carboxylate has been reported.The intermediate ethyl indole-4-carboxylate(3) was obtained from 2-methyl-3-nitrobenzoic acid(1) as raw material by esterification under the catalyst of acid,it was then condensed with N,N-dimethylformamide diethyl acetal,reduced with iron and acetic acid.3 was then reacted with phosphorus oxychloride and N,N-dimethylformamide through Vilsmeier-Hacck reaction,the target product of ethyl 3-formylindole-4-carboxylate was obtained.The total yield reached 57%.The structure of target product was confirmed by IR and (()~1HNMR) and purity was 99.2%.

关 键 词：3-醛基吲哚-4-甲酸乙酯 吲哚-4-甲酸乙酯 合成 

分 类 号：O625[理学—有机化学]