电刺激膈神经中枢端对家兔动脉血压和血浆血管紧张素Ⅱ及肾神经传出放电的影响  

EFFECTS OF ELECTRIC STIMULATION OF THE CENTRAL ENDS OF PHRENIC NERVEON ARTERIAL BLOOD PRESSURE,PLASMAANGIOTENSINⅡ AND RENALNERVEDISCHARGES

作　　者：关宿东[1] 孙凤英[1] 韩永勤[1] 刘桂兰[1] 宋长顺[1] 

机构地区：[1]蚌埠医学院生理学教研组,蚌埠医学院附属医院心内科

出　　处：《中国应用生理学杂志》1995年第3期272-275,共4页Chinese Journal of Applied Physiology

摘　　要：电刺激家兔膈神经中枢端（ＳＣＰＮ）可引起动脉血压下降，此降压反应不能被剪断双侧颈迷走神经或静脉注射阿托品１ｍｇ／ｋｇ所阻断；但可以被静脉注射酚妥拉明２．０ｍｇ／ｋｇ或静脉注射心得安１．５ｍｇ／ｋｇ部分阻断。去除缓冲神经后，其降压反应更明显。降压反应后ｌｍｉｎ血浆血管紧张素Ⅱ水平降低（Ｐ＜０．０５），肾神经传出放电（ＲＮＤ）减少（Ｐ＜０．０１），上述结果表明，膈神经的感觉纤维参与血压调节。Electric stimulation of the central ends of phrenic nerves elicited depressor response in 44anesthetized rabbits. The depressor response could not be inhibited by bilateral vagotomy,but itwas partly inhibited by intravenous injection of phentolamine(2mg/kg)or propranolol(1.5mg/kg).After sinoaortic denervation,the depressor response became more obvious.Thedepressor response was accompanied by a significant decrease in angiotensin Ⅱ(Ang Ⅱ )contentand renal nerve dischages(RND).These results indicate that the phrenic afferents may play a rolein regulation of cardiovascular activities.

关 键 词：膈神经 支脉血压 血管紧张素Ⅱ 肾神经传出放电 

分 类 号：R338.3[医药卫生—人体生理学]