乌苯美司对小鼠脾脏天然杀伤细胞活性的增强作用  

ENHANCEMENT OF UBENIMEX ON MURINE NATURML KILLER CELL ACTIVITY

作　　者：沈炜明[1] 强文安[1] 杜敏琼[1] 李炳生[1] 刘锦荣[1] 陆瑶华[1] 

机构地区：[1]上海市第六人民医院临床药学研究室,华西医科大学,上海医药工业研究院

出　　处：《中国医药工业杂志》1995年第6期255-257,共3页Chinese Journal of Pharmaceuticals

摘　　要：探讨乌苯美司（１）对天然杀伤（ＮＫ）细胞活性的影响。小鼠ｉｇｌ５ｍｇ／（ｋｇ·ｄ）×７ｄ使ＮＫ细胞活性显著升高。对腹腔注射环磷酰胺２００ｍｇ／（ｋｇ·ｄ）×１ｄ所致小鼠ＮＫ细胞活性明显降低，同时ｉｇ１，可使ＮＫ细胞活性恢复。１１０～１００μｇ／ｍｌ与小鼠脾细胞体外保温４８ｈ能显著增强其ＮＫ细胞活性。The effect of ubenimex (Bestatin, 1) on the activity of NK cells is reported. The NK cell activity in mice treated orally with 1 5mg/(kg.d) for 7d was increased compared with the normal ones. Oral administration of 1 could restore the NK activity suppressed by cyclophosphamide (2). Incubation of murine splenocytes in 10～100μg/ml of 1 for 48h significantly enhanced the NK cull activity.

关 键 词：乌苯美司 NK细胞 环磷酰胺 脾脏 

分 类 号：R967[医药卫生—药理学]