间硝苯地平在麻醉兔体内的药动学和药效学  

PHARMACOKINETICS AND PHARMACODYNAMICS OF m-NIFEDIPINE IN ANAESTHETIC RABBITS

作　　者：马骏[1] 谢景文[1] 贾正平[1] 赵德化[1] 许顺尧 

机构地区：[1]兰州军区总医院药材科,第四军医大学

出　　处：《中国医药工业杂志》1995年第10期450-452,共3页Chinese Journal of Pharmaceuticals

摘　　要：麻醉兔静脉注射间硝苯地平后，观察其药动学和药效学。其药物动力学符合二室开放模型。收缩压与舒张压的下降程度均与血药浓度呈显著正相关，而心率的变化却与血药浓度并不显著相关。Pharmacokinetics and pharmacodynamics of m-nifedipine were studied in anaesthetic rabbits after an intravenous injection. Results revealed that pharmacokinetics conformed to a 2-compartment open model. The plasma concentrations were closely correlated with the decreases in SBP and DBP. However, the plasma concentrations were not correlated with the changes in HR.

关 键 词：间硝苯地平 药物动力学 药理学 二氢吡啶类 

分 类 号：R972.4[医药卫生—药品]