雷公藤中的二萜内酯类成分  

Diterpenes constituents of Tripterygium wilfordii

作　　者：林绥[1] 于贤勇[2] 阙慧卿[1] 陈忠[2] 谢狄霖[1] 李援朝[3] 

机构地区：[1]福建省医学科学研究所,福建福州350001 [2]厦门大学化学系,福建厦门361005 [3]中国科学院上海生命研究院上海药物研究所,上海201203

出　　处：《药学学报》2005年第7期632-635,共4页Acta Pharmaceutica Sinica

摘　　要：目的研究雷公藤(Tripterygium wilfordii Hook.F.)的化学成分。方法应用各种色谱技术进行分离纯化,用 UV,IR,~1H NMR,MS,HRMS,~1H-~1H COSY,~1H-^(13)C COSY 和 NOESY 等光谱鉴定化合物的结构。结果共分离得到4个化合物:Ⅰ为16-羟基雷公藤内酯醇(16-hydroxytriptolide),Ⅱ为15-羟基雷公藤内酯醇(雷醇内酯,triptolidenol),Ⅲ为雷公藤乙素(tripdiolide),Ⅳ为雷公藤乙素的差向异构体,命名为2-表雷公藤乙素(2-epitripdiolide)。结论化合物Ⅳ为新二萜内酯化合物。Aim To study the chemical constituents of Tripterygium wilfordii Hook.F.Methods Various column chromatographies with silica gel were used for the isolation and purification.The structures of compounds were established on the basis of its IR,MS,UV,~1H NMR,^(13)C NMR and HRMS,~1H-~1H COSY,~1H-^(13)C COSY and NOESY.Results Four diterpenoids were isolated: 16-hydroxytriptolide(Ⅰ), triptolidenol(Ⅱ),tripdiolide(Ⅲ),2-epitripdiolide(Ⅳ).Conclusion Compound Ⅳ is a new diterpenoid.

关 键 词：雷公藤 二萜内酯 2-表雷公藤乙素 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]