黄花乌头茎叶中一个新的Hetisine型生物碱  

A new hetisine-type alkaloid from the stems and leaves of Aconitum coreanum

作　　者：汤庆发[1] 杨春华[2] 刘静涵[1] 叶文才[1,3] 赵守训[1] 吕扬[4] 冒莉[4] 郑启泰[4] 

机构地区：[1]中国药科大学天然药物化学教研室,江苏南京210009 [2]中国药科大学分析测试中心,江苏南京210009 [3]暨南大学中药及天然药物研究所,北京100050 [4]中国医学科学院,中国协和医科大学药物研究所

出　　处：《药学学报》2005年第7期640-643,共4页Acta Pharmaceutica Sinica

基　　金：国家高技术研究发展计划(863计划)资助项目(2002AA223102).

摘　　要：目的研究黄花乌头茎叶的化学成分。方法采用现代色谱方法进行化学成分分离,并通过各种波谱学分析鉴定化合物的结构。结果从黄花乌头茎叶中分离得到2个化合物,分别鉴定为13-dehydro-1β-acety1-2α,6β-dihydroxyhetisine(Ⅰ)和关附庚素(Ⅱ)。结论Ⅰ为新化合物。Aim To study the chemical constituents of the stems and leaves of Aconitum coreanum (Lèvl.)Rapaics.Methods The constituents of Aconitum coreanum were isolated by using various kinds of modern chromatographic methods.The new alkaloid was identified on the basis of spectral analysis. Results Two compounds were isolated and identified as:13-dehydro-1β-acetyl-2α,6β-dihydroxyhetisine (Ⅰ)and Guanfu base G(Ⅱ).Conclusion Compound Ⅰ is a new alkaloid.

关 键 词：黄花乌头 Hetisine型生物碱 关附午素 

分 类 号：R284.1[医药卫生—中药学]