肺泡巨噬细胞内cAMP和cGMP与肺气虚证的关系  

Relationship Between Defiecient Syndrome of the Lung Qi and cAMP, cGMP of the Alveolar Macrophage

作　　者：宋卫东[1] 赵江云[2] 刘中本[2] 吴华强[2] 张安成[1] 庞玉英[1] 刘丽华[1] 

机构地区：[1]安徽医科大学第一附属医院,安徽230022 [2]安徽中医学院,安徽230038

出　　处：《中国医药学报》1995年第1期21-23,共3页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：检测76例慢性支气管炎患者及36例正常人血、支气管肺灌洗液(BALF)和肺泡巨噬细胞(AM)内cAMP和cGMP。结果表明:①正常人与肺气虚证患者外周血、BALF和AM内cAMP及cGMP无明显差异。②肺气虚证舒喘灵对AM内cAMP之刺激率明显低于正常人,而皮质激素AM内cAMP和cGMP之抑制率明显高于正常人。③研究AM内cAMP及cGMP有助于深入研究肺气虚证的本质。Blood, brancho-alveoli lavage fluid (BALF) and cAMP, cGMP of the alveolar macrophage (AM) of 76 cases of chronic bronchitis and 36 cases of normal persons were examined. Results; (1) There was no difference in the aspects of peripheral blood, BALF, cAMP and cGMP of AM between the normal persons and sufferers of deficient syndrome of the lung qi. (2) The irritation rate of cAMP of AM stimulated by ventolin in the deficient dyndrome of the lung qi was obviously lower than that in the normal persons; while the inhibition rate of cAMP and cGMP of AM inhibited by cortical hormone was notably higher than that in the normal persons. (3) It suggested that to study cAMP and cGMP might be of benefit to the further research of the nature of the deficient syndrome of the lung qi.

关 键 词：肺气虚证 肺泡 巨噬细胞 CAMP CGMP 病理学 

分 类 号：R256.102[医药卫生—中医内科学]