IMPROVING NONTHROMBOGENICITY OF CHITIN WITH ZWITTERIONIC STRUCTURE OF SULFOBETAINE  

作　　者：林思聪 

机构地区：[1]ResearchCenterofSurface＆InterfaceChemistryandEngineeringTechnology,NanjingUniversity,Nanjing210093,China

出　　处：《Chinese Journal of Polymer Science》2005年第4期449-452,共4页高分子科学（英文版）

基　　金：This work was funded by the special fund for major state basic research projects(No.G1999064705).

摘　　要：In order to improve the nonthrombogenicity of chitin,a new monomer,N,N-dimethyl(β-hydroxyethyloxyethyl) ammonium propanesulfonate(DHAPS)was designed,synthesized and grafted onto the chitin membrane by using hexamethylene diisocyanate(HDI)as a coupling agent.Surface analysis of the grafted membranes by ATR-FTIR and XPS confirms that DHAPS has been successfully grafted onto the membrane surface.The platelet resistant property of the grafted membranes was evaluated by a platelet-rich plasma adhesion method.The results showed that platelet-adhesive resistance of the modified membrane has been greatly improved.In order to improve the nonthrombogenicity of chitin,a new monomer,N,N-dimethyl(β-hydroxyethyloxyethyl) ammonium propanesulfonate(DHAPS)was designed,synthesized and grafted onto the chitin membrane by using hexamethylene diisocyanate(HDI)as a coupling agent.Surface analysis of the grafted membranes by ATR-FTIR and XPS confirms that DHAPS has been successfully grafted onto the membrane surface.The platelet resistant property of the grafted membranes was evaluated by a platelet-rich plasma adhesion method.The results showed that platelet-adhesive resistance of the modified membrane has been greatly improved.

关 键 词：CHITIN Nonthrombogenic chitin Zwitterionic biomaterials Surface modification Platelet adhesion 

分 类 号：TB43[一般工业技术]