新疆哈萨克族原发性高血压与心钠素基因G1837A多态性的相关性分析  

The Relationship between ANP Gene G1837A Polymorphism and Essential Hypertension in Xinjiang Kazakans

作　　者：张艳敏[1] 李南方[1] 李涛[1] 周玲[1] 张德燕[1] 李红健[1] 周志明[1] 

机构地区：[1]新疆高血压病研究所新疆自治区人民医院高血压科,乌鲁木齐830001

出　　处：《科学技术与工程》2005年第15期1070-1072,1086,共4页Science Technology and Engineering

基　　金：国家自然科学基金(30260038)资助

摘　　要：探讨新疆哈萨克族原发性高血压与心钠素基因第2内含子上HpaII酶切位点G1837A多态性的相关关系。采用聚合酶链反应-限制性片段长度多态性分析(PCR-RFLP)方法,对287例收缩压≥140 mmHg 和/或舒张压≥90 mmHg的新疆哈萨克族原发性高血压病人和190例年龄、族别相匹配的,血压<140/90 mmHg的血压正常者,分别进行心钠素基因G1837A多态性检测,分析两组中基因型及等位基因频率的分布及其与高血压的相关性。结果心钠素基因G1837A多态性GG、GA和AA三种基因型在新疆哈萨克族人高血压组和血压正常的对照组中的频率分别为0.79、0.20、0.01和0.83、0.16、0.01。G、A两种等位基因的频率分别为0.89、0.11和0.91、0.09。基因型及等位基因的频率在两组间均无统计学差别(X2=1.022,P= 0.312和X2=0.583,P=0.445)。说明心钠素基因G1837A多态性可能与新疆哈萨克族人愿发性高血压无相关性。To investigate the relationship between ANP gene G1837A polymorphism and essential hypertension in Xinjiang Kazakans, the 287 hypertensive patients whose SBP≥140 mmHg and/or DBP≥90 mmHg and 190 normotensive subjects whose BP<140/90 mmHg of Kazakans in Xinjiang are selected. Their ANP gene G1837A polymorphism by PCR-RFLP are measured and tested the association of this polymorphism with hypertension. Three kinds of genotypes of G1837A had got. The distributed frequencies of GG, GA, AA were 0. 79, 0. 20, 0. 01 of hypertensive patients and 0. 83, 0. 16, 0. 01 of controls respectively. The distributed frequencies of G and A allele were 0. 89, 0. 11 of hypertensive patients and 0. 91, 0. 09 of controls respectively. Both of genotypes and allele frequencies had no significant difference between the two groups (X2 = 1. 022,P = 0. 312 and X2=0. 583, P = 0. 445). It is conclused that the ANP G1837A polymorphism may have no association with essential hypertension in Kazakans of Xinjiang.

关 键 词：原发性高血压 心钠素 基因多态性 新疆哈萨克族 

分 类 号：Q349.55[生物学—遗传学]