住院患者抗菌药物治疗与肠道菌群失调的关系研究  

Relationship between antimicrobial treatment and imbalance of intestinal flora in patients during hospitalization period

作　　者：安宇亮[1] 王彦芳[2] 言红键[1] 赵亚敏[1] 尹体英[1] 邢亮[1] 

机构地区：[1]河北省职工医学院附属医院,河北保定071000 [2]河北大学生命科学学院,河北保定071000

出　　处：《中国感染控制杂志》2005年第3期205-207,共3页Chinese Journal of Infection Control

摘　　要：目的　观察住院患者抗菌药物引起的肠道菌群失调(杆菌和球菌比例倒置、细菌计数减少、真菌感染) ,探讨抗菌药物对人肠道菌群的影响。方法　对在某院消化内分泌科住院且使用抗菌药物的患者,采用粪便涂片法观察肠道菌群的变化。结果　粪便杆菌和球菌比例倒置、细菌计数减少与抗菌药物应用种数及疗程相关;真菌感染与用药种数及疗程无相关性。结论　抗菌药物使用种数多、疗程长均会引起患者肠道菌群失调,临床医师应合理使用抗菌药物,同时应监测肠道菌群的变化。Objective To investigate the imbalance of intestinal flora caused by antimicrobial treatment in patients during hospitalization period and to evaluate impact of antimicrobial treatment on intestinal flora. Methods Patients with antimicrobial treatment in digestive and endocrine department were observed, the number of bacteria in intestinal tract was counted through feces smear. Results Inverse ratio between bacilli and cocci, the number of bacteria decrease were associated with kinds and treatment course of antimicrobial application, but fungus infection had no relation with kinds and treatment course of antimicrobial application. Conclusion The overuse of antimicrobial agents can cause imbalance of intestinal flora, clinicians should use antimicrobial agents rationally and monitor the change of intestinal flora.

关 键 词：抗菌药物 肠道菌群失调 合理用药 医院感染 

分 类 号：R969.3[医药卫生—药理学]