肺炎衣原体感染与急性心肌梗死相关性研究  

Correlation between chlamydia pneumoniae infection and acute myocardial infarction

作　　者：刘大男[1] 何作云[1,2] 李金生[3] 

机构地区：[1]第三军医大学新桥医院心内科 [2]550004,贵阳医学院附属医院心内科 [3]贵阳医学院附属医院心内科

出　　处：《中华老年医学杂志》2005年第7期495-498,共4页Chinese Journal of Geriatrics

基　　金：贵州省科学基金资助项目(黔科合字19991177号)Correlationbe

摘　　要：目的探讨肺炎衣原体(Cpn)感染与冠心病心肌梗死的关系。方法测定51例急性心肌梗死、42例陈旧性心肌梗死患者及冠状动脉造影正常的31例健康者、33例非冠心病患者血Cpn抗体水平及DNA,同时观测纤维蛋白原(Fg)、6酮前列腺素F1α(6KetoPGF1α)、血栓素B2(TXB2)、P选择素(GMP140)变化。结果急性心肌梗死组CpnIgG、CpnIgM阳性率及水平高于健康对照组、非冠心病组,CpnDNA检测结果与之吻合。校正冠心病危险因素前、后CpnIgG阳性与急性心肌梗死均有相关性(OR=3.65,P=0.025;OR=3.17,P=0.033)。急性心肌梗死组中Cpn(+)组与Cpn(-)组比较,Fg、TXB2、GMP140水平显著升高,6KetoPGF1α水平显著降低(均为P<0.01);IgG与Fg、TXB2、GMP140呈正相关,与6KetoPGF1α呈负相关。结论Cpn感染与急性心肌梗死存在明显的相关性,与Fg、TXB2、6KetoPGF1α及GMP140也存在相关性。Objective To investigate the correlations between chlamydia pneumoniae (Cpn) infection and acute myocardial infarction(AMI). Methods Specific antibodies and DNA to Cpn were measured in 51 patients with AMI(AMI group),42 patients with elderly myocardial infarction (OMI group) and 31 normal controls (NC group), 33 patients(UC group)who had no angiographic evidence of coronary artery disease. Moreover,the levels of fibrinogen(Fg),6-ketoprostaglandin f1alpha(6-Keto-PGF1α),thromboxane B2(TXB2) and P-selection(GMP 140) were determined in the four groups. Results The prevalence of Cpn IgG antibody was associated with AMI(OR 3.65).Adjustment for the major cardiovascular risk factors did not attenuate this correlation(OR 3.17). Those who were Cpn positive in the AMI group had significantly higher levels of Fg,TXB2 and GMP 140, and a significantly lower level of 6-Keto-PGF1α than those who were Cpn negative in the same group.Correlation analysis revealed that the average concentration of IgG antibody to Cpn was positively associated with the levels of Fg,TXB2 and GMP140 but negatively associated with the level of 6-Keto-PGF1α in the Cpn positive patients of the AMI group. Conclusions There is a significant correlation between Cpn infection and AMI. Cpn infection is associated with the levels of Fg,TXB2, 6-Keto-PGF1α and GMP140 in plasma.

关 键 词：急性心肌梗死 肺炎衣原体感染 6-KETO-PGF1Α 相关性研究 血栓素B2(TXB2) 6-酮前列腺素F1Α GMP140 冠状动脉造影正常 心肌梗死患者 冠心病患者 纤维蛋白原 健康对照组 Cpn感染 抗体水平 P选择素 非冠心病 检测结果 危险因素 

分 类 号：R542.22[医药卫生—心血管疾病] R541.4[医药卫生—内科学]