新生儿氨茶碱药动学研究  

Study on pharmacokinetics of theophylline on neonates

作　　者：王珏[1] 任鼎泰[1] 宋宋[1] 沈健[1] 魏健[1] 梁文权[1] 

机构地区：[1]浙江医科大学附属儿童医院,浙江医科大学药学系

出　　处：《中国医院药学杂志》1995年第12期534-536,共3页Chinese Journal of Hospital Pharmacy

摘　　要：本文采用荧光偏振免疫分析法测定１２例新生儿血中茶碱浓度，氨茶碱剂量按５ｍｇ／ｋｇ恒速静脉滴注。经时采样，测得数据，经分析药时曲线拟合呈一室模型，平均清除速度常数０．０３７±０．００８ｈ￣（－１），平均消除半衰期１９±４ｈ，平均表观分布容积０．８２±０．１４Ｌ／ｋｇ，平均清除率３０±５ｍｌ／（ｈ·ｋｇ）。消除半衰期最大相差２．１倍，显示明显个体差异。Liang Wenquan (Zhejiang Medical University ,Hangzhou 310006)Twelve neonates were given with aminophylline 5mg/kg by constant infusion.The serum concentration oftheophylline was determined by fluorescence polarization immunoassay.Theophylline showed one compartmentmodel,the values of Ke,T_(1'2),Vd and Cl were 0. 037±0.008h￣(-,19 ±4h,0.82±0. 14L/kg and 30±5ml/(h·kg) respectively.The maximum differancein elimination half- life was 2.1 times. It suggested significant individualdifference.

关 键 词：氨茶碱 药物动力学 新生儿 

分 类 号：R974[医药卫生—药品]