清醒羊低氧性肺动脉高压及逆转中肺血管对外源性血小板活化因子的反应  

PULMONARY VASCULAR RESPONSE TO EXOGENOUS PLATELET ACTIVATING FACTOR IN CONSCIOUS SHEEP WITH HYPOXIC PULMONARY HYPERTENSION AND ITS REGRESSION

作　　者：马传桃[1] 

机构地区：[1]湖南医科大学心血管生理研究室

出　　处：《中国应用生理学杂志》1995年第1期30-34,共5页Chinese Journal of Applied Physiology

基　　金：国家自然科学基金

摘　　要：本实验复制了清醒羊低氧性肺动脉高压（ＨＰＨ）及其逆转模型，动态观察了在ＨＰＨ发生、发展及逆转中肺、体循环对外源性血小板活化因子（ＰＡＦ）的反应。结果表明：（１）ＰＡＦ对清醒羊常氧期、ＨＰＨ及ＮＰＨ逆转期均为一强效应肺血管收缩剂，且呈剂量依赖性；（２）ＨＰＨ期：ＰＡＦ对肺血管加压反应增值百分率较常氧期及ＨＰＨ逆转期低；（３）ＰＡＦ对三期体动脉压、心率无明显影响，却能降低各期心输出量。A model of hypoxic pulmonary hypertension(HPH)and its regression was made in 10 con-scious sheep.Hemodynamic response to exogenous platelet activating factor(PAF) was studiedin these sheep.The results were as follows:(1) PAF was a potent pulmonary vasoconstrictor andits effect was dose-dependent;(2) In the hypoxic period,pulmonary vascular pressor responsewas induced bY PAF,but the value of % increase in PAP was less than in normoxic period andregression period;(3) PAF did not change systemic arterial pressure and heart rate,but de-creased cardiac output during the three periods.

关 键 词：血小板活化因子 肺血管 低氧性 肺动脉高压 

分 类 号：R543.202[医药卫生—心血管疾病]