降钙素基因相关肽对小鼠肠道集合淋巴结T细胞及腹腔巨噬细胞功能的影响  

EFFECT OF CALCITONIN GENE RELATED PEPTIDE ON PEYER'S PATCH T LYMPHOCYTES AND PERITONEAL MACROPHAGES IN MICE

作　　者：黄忠[1] 李铁[1] 于吉人[1] 

机构地区：[1]北京医科大学生理学系

出　　处：《中国应用生理学杂志》1995年第4期326-329,共4页Chinese Journal of Applied Physiology

基　　金：国家自然科学基金资助课题

摘　　要：本工作观察了降钙素基因相关肽（ＣＧＲＰ）对小鼠肠集合淋巴小结（ＰＰ结）Ｔ细胞和小鼠腹腔巨噬细胞功能的影响。结果表明：ＣＧＲＰ能明显抑制ＰＰ结Ｔ淋巴细胞的转化，并且这种作用与Ｔ细胞的分化增殖状态有明显关系。此外ＣＧＲＰ对腹腔巨噬细胞ＤＮＡ和蛋白质的合成也有明显的抑制作用。以上结果提示ＣＣＲＰ可能作为一种抑制型的神经内分泌免疫调节肽而对肠道免疫功能发挥着重要的调节作用。The effect of calcitonin gene related peptide(CGRP) on Peye's patch T lymphocytes andperitoneal macrophages in mice were observed.The results suggested that CGRP potently inhib-ited proliferation of Peye's patch T lymphocyte stimulated by ConA in vitro, and this effect va-ried with different proliferation and differentiation stages of T lymphocyte. Morever, it was foundthat CGRP inhibited the DNA and protein synthesis of peritoneal macrophages in mice.Theabove results implicate that CGRP plays an important role in neuroimmune modulation as anegative regulatory peptide.

关 键 词：降钙素基因 相关肽 T细胞 巨噬细胞 免疫调节 

分 类 号：R392.1[医药卫生—免疫学]