通脉降脂口服液对体外培养兔主动脉壁平滑肌细胞生长周期的实验研究  

Experimental Study on Cell Cycle in Rabbits'Aortic Smooth Mascle Cell Culture in Vitro with Tongmai Jiangzhi Liquor

作　　者：孙小宣[1] 胡毅煌[1] 包晓峰[1] 王秀凤[1] 刘志云[1] 徐铭渔[1] 翁维良[1] 

机构地区：[1]中国中医研究院北京针灸骨伤学院附属医院,中国中医研究院西苑医院

出　　处：《中国中西医结合杂志》1995年第3期168-169,共2页Chinese Journal of Integrated Traditional and Western Medicine

基　　金："八.五"国家科技攻关课题

摘　　要：报告了通脉降脂口服液对体外培养的兔主动脉壁中层平滑肌细胞（Ｓｍｏｏｔｈｍｕｓｃｌｅｃｅｌｌ，ＳＭＣ）周期动力学的影响。观察到１．５％、２．０％浓度的通脉降脂口服液随着加药培养时间的延长，可使Ｇ０／Ｇ１期ＳＭＣ所占百分比逐渐减低，Ｓ期ＳＭＣ百分比逐渐升高，而且药物浓度较高时这种作用更为明显。提示通脉降脂口服液对体外培养兔主动脉壁中层ＳＭＣ的增殖有明显的抑制作用。The effects of Tongmai Jiangzhi Liquor (TMJZL) on the cell cycle kinetics in smooth muscle cell (SMC) of rabbits' midlayer of aortic wall was observed. It was showed that TMJZL could extend the time of cell culture, lower the percentage of SMC in G_0/G_1 phase and elevate the percentage of SMC in S phase gradually. The higher the concentration, the stronger the effect. The experiment showed that TMJZL had a marked inhibition of SMC of rabbits' midlayer of aortic wallcultured in vitro.

关 键 词：通脉降低口服液 平滑肌细胞 细胞周期 实验 

分 类 号：R285.5[医药卫生—中药学]