Resveratrol enhances on the proliferation and osteoblastic differentiation of BMSCs through MAPK and ER／NO／cGMP pathways  

作　　者：Ya-linLI Li-huaSONG Zhi-jieDAI Zhou-shengXIAO 

机构地区：[1]InstituteofClinicalPharmacology,CentralSouthUniversity,Changsha,Hunan410078

出　　处：《中国药理通讯》2005年第2期18-19,共2页

摘　　要：AIM The stimulatory effect of resveratrol ( Resv, a natural phytoestrogen) has been reported on osteoblasts in vitro, whereas cyclosporine A (CsA, an immunosuppressant) was associated with bone loss in vivo. This project is intend to investigate the in vitro effect of Resv and CsA on osteoblastic differentiation in bone marrow-derived mesenchymal stem cells (BMSCs), and tries to identify whether the MAPK or ER/NO/cGMP pathway is involved in the stimulatory effect of Resv on BMSCs.

关 键 词：分芽繁殖 造骨细胞 BMSCS MAPK ER/NO/cGMP 骨疾病 

分 类 号：R681[医药卫生—骨科学]