糖基化低密度脂蛋白、氧化低密度脂蛋白和2型糖尿病合并冠心病的关系  

Glycosylated low-density lipoprotein and oxidized low-density lipoprotein in type 2 diabetes mellitus with coronary heart disease

作　　者：苏文凌[1] 高桦[1] 李军[1] 高玉琪[1] 

机构地区：[1]天津医科大学总医院内分泌科,天津300052

出　　处：《天津医科大学学报》2005年第2期198-200,共3页Journal of Tianjin Medical University

摘　　要：目的:探讨血清糖基化低密度脂蛋白和血浆氧化低密度脂蛋白在2型糖尿病合并冠心病的作用。方法:测定89例2型糖尿病患者和30例正常对照的血清糖基化低密度脂蛋白和血浆氧化低密度脂蛋白水平,血清糖基化低密度脂蛋白采用氯化硝基四氮唑蓝比色法,血浆氧化低密度脂蛋白采用酶联免疫吸附法测定。结果:(1)2型糖尿病患者血清糖基化低密度脂蛋白(0.398±0.081)mmol/L与正常对照组相比增高(0.268±0.074)mmol/L;2型糖尿病患者血浆氧化低密度脂蛋白(58.264±24.201)ug/dl明显高于对照组(33.35±8.341)ug/dl,差异均有显著性(P<0.01)。(2)2型糖尿病并发冠心病组的血清糖基化低密度脂蛋白(0.414±0.074)mmol/L较无冠心病组(0.373±0.085)mmol/L增高、血浆氧化低密度脂蛋白水平2型糖尿病并发冠心病组(64.685±22.225)ug/dl显著高于无冠心病组(48.357±24.430)ug/dl,差异均有显著性(P<0.01)。(3)2型糖尿病患者血清糖化低密度脂蛋白与血浆氧化低密度脂蛋白正相关(r=0.713,P<0.01)。结论:糖基化低密度脂蛋白和氧化低密度脂蛋白与2型糖尿病合并冠心病有关。Objective To study the relationship between type 2 diabetes mellitus with coronary heart disease and the serum GLDL or the plasma OXLDL. Methods The levels of the serum GLDL was measured by a fructosamine method and that of the plasma OXLDL was estimated by ELISA in 89 cases with type 2 diabetes mellitus and in 30 controls. Results 1The levels of both the serum GLDL and the plasma OXLDL in type 2 diabetes mellitus were significantly higher than those in controls P<0.01. 2The levels of both the serum GLDL and the plasma OXLDL in type 2 diabetes mellitus with coronary heart disease increased significantly in comparison with type 2 diabetes mellitus without coronary heart disease P<0.01.3Positive correlation was found between the levels of the serum GLDL and that of the plasma OXLDL r=0.713,P<0.01. Conclusion The measurements of GLDL and OXLDL have very important clinical value in type 2 diabetes mellitus with coronary heart disease.

关 键 词：2型糖尿病 冠心病 糖基化低密度脂蛋白 氧化低密度脂蛋白 

分 类 号：Q546[生物学—生物化学] R587.1[医药卫生—内分泌]