去势对心肌梗死后雄兔心衰心功能的影响  

Effect of castration on the heart function in postinfarction congestive heart failure model in male rabbits

作　　者：樊瑾[1] 李小鹰[1] 娄卫民[1] 沈正[1] 

机构地区：[1]解放军总医院老年心内科,北京100853

出　　处：《解放军医学杂志》2005年第7期626-627,共2页Medical Journal of Chinese People's Liberation Army

基　　金：总后卫生部临床高新技术重大项目建设基金([2002]卫医字18号)

摘　　要：目的观察去势对心肌梗死后心衰雄兔心功能的影响。方法将32只4～5月龄健康雄性新西兰大白兔随机分为心肌梗死组(MI组,行冠状动脉结扎术,n=24)和假手术组(n=8)。MI组独立笼养3周后存活模型兔20只,随机分为2组,去势组(行去势术,n=10)和假去势组(n=10)。第0、3、15周复查血清游离睾酮(FT)、硫酸脱氢表雄酮(DHEAS)浓度,并测量左室射血分数(LVEF),第15周检测心脏腔径大小。结果心肌梗死3周后血清FT和DHEAS水平显著下降。心肌梗死15周时,与假手术组比较,MI组雄激素水平下降、心重占体重百分比、体重校正的左右心室舒张末内径、室壁厚度均增加。去势组雄激素水平和体重下降较假去势组更明显。与假去势组和去势前比较,去势组LVEF无改善。结论去势对心衰雄兔心功能无有益影响。Objective To investigate the effect of castration on heart function in male rabbits postinfarction congestive heart failure model. Methods 32 male 4-5 months old New Zealand rabbits were randomly assigned to ligation of first branch of left coronary artery or sham operation (sham group, n=8). 3 weeks later 20 survived MI model rabbits were randomly subjected to castration (castration group, n=10) or sham operation (MI group, n=10). Serum FT, DHEAS levels and LVEF were checked at week 0, 3 and 15. Heart diameter and left ventricular wall thickness were measured at week 15. Results The serum FT and DHEAS levels decreased significantly at week 3. In MI group and castration group serum androgen level was lower and heart weight, ventricular diameters, ventricular wall thickness corrected by body weight were higher than that in sham group at week 15. The androgen level and body weight of castration group were lower than that in MI group. But LVEF in castration group was not higher than MI group. Conclusion There was no benefit effect of castration on heart function in male rabbits postinfarction congestive heart failure model.

关 键 词：兔 心肌梗死 心力衰竭 去势 

分 类 号：R541[医药卫生—心血管疾病]